-
1.发明公开Vaccine and serum for endotoxin associated disease and method of preparing same as well as methods of immunisation and treatment of such disease and to a detoxified endotoxin and bacterial mutant 失效疫苗和血清内毒素相关的疾病和它们的制造和用于免疫和治疗这些疾病的，并且细菌内毒素突变体enttoxifierte方法的方法。
公开(公告)号：EP0158282A2
公开(公告)日：1985-10-16
申请号：EP85104085.7
申请日：1985-04-03
IPC分类号： A61K39/112 , A61K39/40 , A61K39/02
CPC分类号： C12R1/42 , A61K38/00 , A61K39/0275 , A61K39/39 , A61K2039/521 , A61K2039/55572 , A61K2039/55583 , A61K2039/55594 , C07K16/1228 , C07K16/1232 , C07K16/1235 , Y02A50/482
摘要： A combination vaccine, with methods of preparation and treatment, for protection against Gram negative bacterial diseases. The vaccine includes a killed suspension of a bacterial mutant from the taxonomic family Enterobacteriaceae, a B-lymphocyte proliferating immune modulator, and a protein and lipid binding adjuvant. A hyperimmune serum for treating diseased animals is prepared by vaccinating a donor animal with the combination vaccine and then preparing clot serum containing antigen specific antibodies. The mutant is ATCC No. 53000 and is produced by ionizing radiation of Salmonella enteritidis. The immune modulator is a detoxified extract of lipopolysaccharide and is useful with many antigens to enhance primary immune response.
摘要翻译： 的组合疫苗，其中制备和处理的方法，对革兰氏阴性细菌性疾病的保护。 该疫苗包括从分类学肠杆菌科，B-淋巴细胞增殖免疫调节剂的细菌突变体的杀死悬浮液，以及蛋白质和脂质结合佐剂。 对于治疗患病动物甲超免疫血清通过接种的供体动物与所述组合疫苗，然后制备凝块含有血清的抗原特异性抗体制备。 所述突变体是ATCC号 53000，并且由电离肠炎沙门氏菌的辐射产生。 免疫调节剂是脂多糖的解毒提取物和与许多抗原以增强初级免疫应答是有用的。
-
2.发明授权Vaccine and serum for endotoxin associated disease and method of preparing same as well as methods of immunisation and treatment of such disease and to a detoxified endotoxin and bacterial mutant 失效疫苗和血清内毒素相关的疾病和它们的制造和用于免疫和治疗这些疾病的，并且细菌内毒素突变体enttoxifierte方法的方法。
公开(公告)号：EP0158282B1
公开(公告)日：1993-12-15
申请号：EP85104085.7
申请日：1985-04-03
IPC分类号： A61K39/112 , A61K39/40 , A61K39/02
CPC分类号： C12R1/42 , A61K38/00 , A61K39/0275 , A61K39/39 , A61K2039/521 , A61K2039/55572 , A61K2039/55583 , A61K2039/55594 , C07K16/1228 , C07K16/1232 , C07K16/1235 , Y02A50/482
摘要： A combination vaccine, with methods of preparation and treatment, for protection against Gram negative bacterial diseases. The vaccine includes a killed suspension of a bacterial mutant from the taxonomic family Enterobacteriaceae, a B-lymphocyte proliferating immune modulator, and a protein and lipid binding adjuvant. A hyperimmune serum for treating diseased animals is prepared by vaccinating a donor animal with the combination vaccine and then preparing clot serum containing antigen specific antibodies. The mutant is ATCC No. 53000 and is produced by ionizing radiation of Salmonella enteritidis. The immune modulator is a detoxified extract of lipopolysaccharide and is useful with many antigens to enhance primary immune response.
-
3.发明公开Hyperimmune serum for endotoxin associated disease, detoxified endotoxin and bacterial mutant 失效内毒素 - 内毒素Krankheiten的超免疫毒素，enttoxifierte内毒素和bakterielle突变体。
公开(公告)号：EP0540063A1
公开(公告)日：1993-05-05
申请号：EP92121329.4
申请日：1985-04-03
CPC分类号： C12R1/42 , A61K38/00 , A61K39/0275 , A61K39/39 , A61K2039/521 , A61K2039/55572 , A61K2039/55583 , A61K2039/55594 , C07K16/1228 , C07K16/1232 , C07K16/1235 , Y02A50/482
摘要： A hyperimmune serum for treating diseased animals is prepared by vaccinating a donor animal with a combination vaccine and then preparing clot serum containing antigen specific antibodies. The mutant is ATCC No. 53000 and is produced by ionizing radiation of Salmonella enteritidis . The immune modulator is a detoxified extract of lipopolysaccharide and is useful with many antigens to enhance primary immune response.
摘要翻译： 通过用组合疫苗接种供体动物，然后制备含有抗原特异性抗体的凝块血清，制备用于治疗患病动物的超免疫血清。 突变体是ATCC No.53000，通过电离沙门氏菌的辐射来产生。 免疫调节剂是脂多糖的解毒提取物，并且可用于许多抗原以增强初级免疫应答。
-
4.发明公开Vaccine and serum for endotoxin associated disease and method of preparing same as well as methods of immunisation and treatment of such disease and to a detoxified endotoxin and bacterial mutant 失效用于内毒素相关疾病的疫苗和血清及其制备方法以及作为这种疾病的免疫和治疗方法以及脱氧内毒素和细菌突变体
公开(公告)号：EP0158282A3
公开(公告)日：1988-05-25
申请号：EP85104085
申请日：1985-04-03
IPC分类号： A61K39/112 , A61K39/40 , A61K39/02
CPC分类号： C12R1/42 , A61K38/00 , A61K39/0275 , A61K39/39 , A61K2039/521 , A61K2039/55572 , A61K2039/55583 , A61K2039/55594 , C07K16/1228 , C07K16/1232 , C07K16/1235 , Y02A50/482
摘要： A combination vaccine, with methods of preparation and treatment, for protection against Gram negative bacterial diseases. The vaccine includes a killed suspension of a bacterial mutant from the taxonomic family Enterobacteriaceae, a B-lymphocyte proliferating immune modulator, and a protein and lipid binding adjuvant. A hyperimmune serum for treating diseased animals is prepared by vaccinating a donor animal with the combination vaccine and then preparing clot serum containing antigen specific antibodies. The mutant is ATCC No. 53000 and is produced by ionizing radiation of Salmonella enteritidis. The immune modulator is a detoxified extract of lipopolysaccharide and is useful with many antigens to enhance primary immune response.
-
-
-
搜索结果
4 条记录 (耗时 0.012 秒)
