发明公开
EP0162323A1 Stable sulpho-adenosyl-l-methionine (same) salts, particularly suitable for parenteral use
失效
稳定磺基腺苷-L-蛋氨酸盐，特别是适合于肠胃外使用。
- 专利标题： Stable sulpho-adenosyl-l-methionine (same) salts, particularly suitable for parenteral use
- 专利标题（中）： 稳定磺基腺苷-L-蛋氨酸盐，特别是适合于肠胃外使用。
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申请号： EP85105000.5申请日： 1985-04-25
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公开(公告)号： EP0162323A1公开(公告)日： 1985-11-27
- 发明人: Gennari, Federico
- 申请人： BIORESEARCH S.p.A.
- 申请人地址： Località Roggia Pirola I-20060 Liscate Milano IT
- 专利权人： BIORESEARCH S.p.A.
- 当前专利权人： BIORESEARCH S.p.A.
- 当前专利权人地址： Località Roggia Pirola I-20060 Liscate Milano IT
- 代理机构： Gervasi, Gemma, Dr.
- 优先权： IT2093884 19840516
- 主分类号： C07H19/16
- IPC分类号： C07H19/16 ; A61K31/70
摘要：
@ The present invention relates to new stable sulpho-adenosyl-L-methionine (SAMe) salts particularly suitable for parenteral use, their production process, and pharmaceutical compositions containing them as active principles.
Said salts correspond to the general formula:
where n can vary from 1 to 2 and m can vary from 3 to 12.
The process for producing said salts consists of the following stages: a) enriching the starting yeast with SAMe; b) lysing the cells and recovering a solution rich in SAMe (cell lysate): c) prepurifying the cell lysate by ultrafiltration; d) passing the prepurified lysate through a column of weak acid ion exchange resin and eluting with the required disulphonic acid; e) passing the eluate of said column through a column of absorption resin and washing with the required disulphonic acid; f) concentrating the eluate of the latter column by reverse osmosis; g) drying the concentrated solution.
Said salts correspond to the general formula:
where n can vary from 1 to 2 and m can vary from 3 to 12.
The process for producing said salts consists of the following stages: a) enriching the starting yeast with SAMe; b) lysing the cells and recovering a solution rich in SAMe (cell lysate): c) prepurifying the cell lysate by ultrafiltration; d) passing the prepurified lysate through a column of weak acid ion exchange resin and eluting with the required disulphonic acid; e) passing the eluate of said column through a column of absorption resin and washing with the required disulphonic acid; f) concentrating the eluate of the latter column by reverse osmosis; g) drying the concentrated solution.
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