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47 条记录 (耗时 0.013 秒)

    Use of S-adenosyl-L-methionine in the treatment of intrahepatic cholestasis determined by total parenteral nutrition
    4.
    发明公开
    Use of S-adenosyl-L-methionine in the treatment of intrahepatic cholestasis determined by total parenteral nutrition 失效
    S-腺苷-L-蛋氨酸的用于治疗全胃肠​​外营养肝内胆汁淤积症引起的。

    公开(公告)号：EP0501293A1

    公开(公告)日：1992-09-02

    申请号：EP92102730.6

    申请日：1992-02-19

    申请人： BIORESEARCH S.p.A.

    发明人： Bortolini, Michele

    IPC分类号： A61K31/70

    CPC分类号： A61K31/70

    摘要： The invention relates to the use of S-adenosyl-L-methionine (SAMe) in the form of pharmaceutically acceptable salts in the preparation of injectable pharmaceutical compositions for the prevention and symptomatic treatment of intrahepatic cholestasis determined by total parenteral nutrition.

    摘要翻译： 本发明涉及在制备可注射的药物组合物的用于预防和由全肠外营养开采肝内胆汁淤积症确定性的对症治疗中药学上可接受的盐的形式使用S-腺苷-L-甲硫氨酸（相同）的。

    New cytidine-diphosphocholine salts, particularly suitable for oral use
    8.
    发明公开
    New cytidine-diphosphocholine salts, particularly suitable for oral use 失效
    新型CYDIDINE-DIPHOSPHOCHOLINE SALTS，特别适用于口服使用

    公开(公告)号：EP0207436A3

    公开(公告)日：1988-01-27

    申请号：EP86108677

    申请日：1986-06-25

    申请人： BIORESEARCH S.p.A.

    发明人： Gennari, Federico

    IPC分类号： C07H19/10 ,  A61K31/70

    CPC分类号： C07H19/10

    摘要： New cytidine-diphosphocholine (CDP-choline) salts with long-alkyl chain sulphonic acids suitable for injectable pharmaceutical formulations, but more specifically for oral formulations. Said salts are prepared by a process comprising preparing an aqueous solution of basic CDP-choline, preparing an aqueous sulphonic acid solution, reacting these two solutions together to obtain the required salt, and recovering this salt with a high degree of purity.

    Stable sulpho-adenosyl-l-methionine (same) salts, particularly suitable for parenteral use
    9.
    发明公开
    Stable sulpho-adenosyl-l-methionine (same) salts, particularly suitable for parenteral use 失效
    稳定磺基腺苷-L-蛋氨酸盐，特别是适合于肠胃外使用。

    公开(公告)号：EP0162323A1

    公开(公告)日：1985-11-27

    申请号：EP85105000.5

    申请日：1985-04-25

    申请人： BIORESEARCH S.p.A.

    发明人： Gennari, Federico

    IPC分类号： C07H19/16 ,  A61K31/70

    CPC分类号： C07H19/16 ,  Y10S435/921 ,  Y10S435/942

    摘要： @ The present invention relates to new stable sulpho-adenosyl-L-methionine (SAMe) salts particularly suitable for parenteral use, their production process, and pharmaceutical compositions containing them as active principles.
    Said salts correspond to the general formula:
    where n can vary from 1 to 2 and m can vary from 3 to 12.
    The process for producing said salts consists of the following stages: a) enriching the starting yeast with SAMe; b) lysing the cells and recovering a solution rich in SAMe (cell lysate): c) prepurifying the cell lysate by ultrafiltration; d) passing the prepurified lysate through a column of weak acid ion exchange resin and eluting with the required disulphonic acid; e) passing the eluate of said column through a column of absorption resin and washing with the required disulphonic acid; f) concentrating the eluate of the latter column by reverse osmosis; g) drying the concentrated solution.