发明公开
EP0162414A2 Amphipathic peptides and pharmaceutical compositions containing same
失效
Amphipatische Peptide und deren pharmazeutische Zusammensetzung。
- 专利标题： Amphipathic peptides and pharmaceutical compositions containing same
- 专利标题（中）： Amphipatische Peptide und deren pharmazeutische Zusammensetzung。
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申请号： EP85105990.7申请日： 1985-05-15
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公开(公告)号： EP0162414A2公开(公告)日： 1985-11-27
- 发明人: Segrest, Jere P. , Anantharamaiah, Gattadahalli M.
- 申请人： Research Corporation
- 申请人地址： Suite 853, 25 Broadway New York New York 10004 US
- 专利权人： Research Corporation
- 当前专利权人： Research Corporation
- 当前专利权人地址： Suite 853, 25 Broadway New York New York 10004 US
- 代理机构： Lehn, Werner, Dipl.-Ing.
- 优先权： US610444 19840515
- 主分类号： C07K7/08
- IPC分类号： C07K7/08 ; A61K37/02
摘要：
A peptide capable of forming an amphipathic helix containing a sequence comprising
wherein
A,, A 2 , A 3 and A 4 are independently aspartic acid or glutamic acid, or homologues or analogues thereof;
B,, B 2 , B 3 , B 4 , B 5 , B 6 , B 7 , B 7 , and B 9 are independently tryptophan, phenylalanine, leucine, alanine, tyrosine, isoleucine, valine or α-naphthylalanine, or homologues or analogues thereof; C 1 , C 2 , C 3 , and C 4 are independently lysine or arginine, or homologues, or analogues thereof, and D is serine, threonine, alanine, glycine, or histidine; provided that, when A, and A 2 are aspartic acid, A 3 and A 4 are glutamic acid, B 2 and B 7 are leucine B 3 and B 9 are phenylalanine, B 4 is tyrosin B 5 is valine, C,, C 2 , C 3 , and C 4 are lysine, B 6 , B 6 , and D are alanine, B, is not tryptophan, and a pharmaceutical composition containing said peptide.
wherein
A,, A 2 , A 3 and A 4 are independently aspartic acid or glutamic acid, or homologues or analogues thereof;
B,, B 2 , B 3 , B 4 , B 5 , B 6 , B 7 , B 7 , and B 9 are independently tryptophan, phenylalanine, leucine, alanine, tyrosine, isoleucine, valine or α-naphthylalanine, or homologues or analogues thereof; C 1 , C 2 , C 3 , and C 4 are independently lysine or arginine, or homologues, or analogues thereof, and D is serine, threonine, alanine, glycine, or histidine; provided that, when A, and A 2 are aspartic acid, A 3 and A 4 are glutamic acid, B 2 and B 7 are leucine B 3 and B 9 are phenylalanine, B 4 is tyrosin B 5 is valine, C,, C 2 , C 3 , and C 4 are lysine, B 6 , B 6 , and D are alanine, B, is not tryptophan, and a pharmaceutical composition containing said peptide.
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