公开(公告)号：EP0162414A2

公开(公告)日：1985-11-27

申请号：EP85105990.7

申请日：1985-05-15

申请人： Research Corporation

发明人： Segrest, Jere P. ,  Anantharamaiah, Gattadahalli M.

IPC分类号： C07K7/08 ,  A61K37/02

CPC分类号： C07K14/775 ,  A61K38/00

摘要： A peptide capable of forming an amphipathic helix containing a sequence comprising

wherein

A,, A 2 , A 3 and A 4 are independently aspartic acid or glutamic acid, or homologues or analogues thereof;
B,, B 2 , B 3 , B 4 , B 5 , B 6 , B 7 , B 7 , and B 9 are independently tryptophan, phenylalanine, leucine, alanine, tyrosine, isoleucine, valine or α-naphthylalanine, or homologues or analogues thereof; C 1 , C 2 , C 3 , and C 4 are independently lysine or arginine, or homologues, or analogues thereof, and D is serine, threonine, alanine, glycine, or histidine; provided that, when A, and A 2 are aspartic acid, A 3 and A 4 are glutamic acid, B 2 and B 7 are leucine B 3 and B 9 are phenylalanine, B 4 is tyrosin B 5 is valine, C,, C 2 , C 3 , and C 4 are lysine, B 6 , B 6 , and D are alanine, B, is not tryptophan, and a pharmaceutical composition containing said peptide.

摘要翻译： 能够形成包含以下序列的两亲性螺旋的肽：A1-B1-B2-C1-D-B3-B4-A2-C2-B5-B6-A3 C3-B7-C4-A4-B8-B9 ...其中... A1，A2，A3和A4分别是天冬氨酸或谷氨酸，或其同系物或类似物; B1，B2，B3，B4，B5，B6，B7，B7和B9独立地是色氨酸，苯丙氨酸，亮氨酸，丙氨酸， 酪氨酸，异亮氨酸，缬氨酸或α-萘基丙氨酸，或其同系物或类似物; C1，C2，C3和C4独立地是赖氨酸或精氨酸或其同系物或类似物，D是丝氨酸，苏氨酸，丙氨酸，甘氨酸或组氨酸; 条件是当A1和A2是天冬氨酸时，A3和A4是谷氨酸，B2和B7是亮氨酸B3，B9是苯丙氨酸，B4是酪氨酸B5是缬氨酸，C1，C2，C3和C4是赖氨酸，B6，B8 ，D是丙氨酸，B1不是色氨酸，以及含有所述肽的药物组合物。

公开(公告)号：EP0162414A3

公开(公告)日：1987-12-09

申请号：EP85105990

申请日：1985-05-15

申请人： Research Corporation

发明人： Segrest, Jere P. ,  Anantharamaiah, Gattadahalli M.

IPC分类号： C07K07/08 ,  A61K37/02

CPC分类号： C07K14/775 ,  A61K38/00

摘要： A peptide capable of forming an amphipathic helix containing a sequence comprising
wherein
A,, A 2 , A 3 and A 4 are independently aspartic acid or glutamic acid, or homologues or analogues thereof; B,, B 2 , B 3 , B 4 , B 5 , B 6 , B 7 , B 7 , and B 9 are independently tryptophan, phenylalanine, leucine, alanine, tyrosine, isoleucine, valine or α-naphthylalanine, or homologues or analogues thereof; C 1 , C 2 , C 3 , and C 4 are independently lysine or arginine, or homologues, or analogues thereof, and D is serine, threonine, alanine, glycine, or histidine; provided that, when A, and A 2 are aspartic acid, A 3 and A 4 are glutamic acid, B 2 and B 7 are leucine B 3 and B 9 are phenylalanine, B 4 is tyrosin B 5 is valine, C,, C 2 , C 3 , and C 4 are lysine, B 6 , B 6 , and D are alanine, B, is not tryptophan, and a pharmaceutical composition containing said peptide.