发明公开
EP0177361A3 Octahydroindolo-[2,3-a]quinolizin-l-yl-alkanecarboxylic acid amides and salts thereof
失效
OCTAHYDROINDOLO-Û2,3-A-喹诺酮-L-缬氨酸羧基酰胺及其盐
- 专利标题： Octahydroindolo-[2,3-a]quinolizin-l-yl-alkanecarboxylic acid amides and salts thereof
- 专利标题（中）： OCTAHYDROINDOLO-Û2,3-A-喹诺酮-L-缬氨酸羧基酰胺及其盐
-
申请号： EP85307113申请日： 1985-10-04
-
公开(公告)号： EP0177361A3公开(公告)日： 1987-09-02
- 发明人: Soti, Ferenc , Szantay, Csaba , Incze, Maria , Balogh, Zsuzsanna , Ezer, Elemer , Matuz, Judit , Szporny, Laszlo , Hajos, Gyorgy , Kuthi, Csaba
- 申请人： RICHTER GEDEON VEGYESZETI GYAR R.T.
- 专利权人： RICHTER GEDEON VEGYESZETI GYAR R.T.
- 当前专利权人： RICHTER GEDEON VEGYESZETI GYAR R.T.
- 优先权： HU377684 19841005
- 主分类号： C07D471/14
- IPC分类号： C07D471/14 ; A61K31/395 ; C07D221/00 ; C07D209/00
摘要：
The invention relates to new 1,2,3,4,6,7,12,12b-octahydroindolo[2,3-a]quinolizin-1-yl-alkanecarboxylic acid amides of the general formula (I),
wherein
R, and R 2 represent a hydrogen or halogen atom, or a hydroxyl, nitro or C 1-4 alkoxy group; R 3 and R 4 represent a hydrogen atom or a C 1-4 alkyl group; R 5 and R 6 represent a hydrogen atom, C 1-8 alkyl group, C 3-8 alkenyl or cycloalkyl group, aryl or aralkyl group, heteroaryl or heteroaralkyl goup containing oxygen, nitrogen or sulphur atom, all these goups being optionally substituted; or R 5 and R 6 together represent a,w-alkyl group, wherein one carbon atom may optionally be replaced by an oxygen or nitrogen atom; and G means a C 1-4 straight chained alkylidene group, as well as to their therapeutically useful acid addition salts and pharmaceutical compositions containing these compounds. Furthermore, the invention relates to a process for preparing these compounds and compositions. The compounds of the general formula (I) have valuable therapeutic properties, namely vasodilatory, spasmolytic, antiarrhythmic and gastrocytoprotective effects. The gastrocytoprotective effect is particularly important.
wherein
R, and R 2 represent a hydrogen or halogen atom, or a hydroxyl, nitro or C 1-4 alkoxy group; R 3 and R 4 represent a hydrogen atom or a C 1-4 alkyl group; R 5 and R 6 represent a hydrogen atom, C 1-8 alkyl group, C 3-8 alkenyl or cycloalkyl group, aryl or aralkyl group, heteroaryl or heteroaralkyl goup containing oxygen, nitrogen or sulphur atom, all these goups being optionally substituted; or R 5 and R 6 together represent a,w-alkyl group, wherein one carbon atom may optionally be replaced by an oxygen or nitrogen atom; and G means a C 1-4 straight chained alkylidene group, as well as to their therapeutically useful acid addition salts and pharmaceutical compositions containing these compounds. Furthermore, the invention relates to a process for preparing these compounds and compositions. The compounds of the general formula (I) have valuable therapeutic properties, namely vasodilatory, spasmolytic, antiarrhythmic and gastrocytoprotective effects. The gastrocytoprotective effect is particularly important.
信息查询
