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29 条记录 (耗时 0.012 秒)

    Octahydroindolo-[2,3-a]quinolizin-l-yl-alkanecarboxylic acid amides and salts thereof
    4.
    发明公开
    Octahydroindolo-[2,3-a]quinolizin-l-yl-alkanecarboxylic acid amides and salts thereof 失效
    八氢吲哚-2-磺酸盐-1-基 - 烷烃 - 羧基酰胺和硫酸盐

    公开(公告)号：EP0177361A2

    公开(公告)日：1986-04-09

    申请号：EP85307113.2

    申请日：1985-10-04

    申请人： RICHTER GEDEON VEGYESZETI GYAR R.T.

    发明人： Soti, Ferenc ,  Szantay, Csaba ,  Incze, Maria ,  Balogh, Zsuzsanna ,  Ezer, Elemer ,  Matuz, Judit ,  Szporny, Laszlo ,  Hajos, Gyorgy ,  Kuthi, Csaba

    IPC分类号： C07D471/14 ,  A61K31/395

    CPC分类号： C07D471/14

    摘要： The invention relates to new 1,2,3,4,6,7,12,12b-octahydroindolo[2,3-a]quinolizin-1-yl-alkanecarboxylic acid amides of the general formula (I),
    wherein

    R, and R 2 represent a hydrogen or halogen atom, or a hydroxyl, nitro or C 1-4 alkoxy group;
    R 3 and R 4 represent a hydrogen atom or a C 1-4 alkyl group;
    R 5 and R 6 represent a hydrogen atom, C 1-8 alkyl group, C 3-8 alkenyl or cycloalkyl group, aryl or aralkyl group, heteroaryl or heteroaralkyl goup containing oxygen, nitrogen or sulphur atom, all these goups being optionally substituted; or
    R 5 and R 6 together represent a,w-alkyl group, wherein one carbon atom may optionally be replaced by an oxygen or nitrogen atom; and
    G means a C 1-4 straight chained alkylidene group, as well as to their therapeutically useful acid addition salts and pharmaceutical compositions containing these compounds.

    Furthermore, the invention relates to a process for preparing these compounds and compositions.
    The compounds of the general formula (I) have valuable therapeutic properties, namely vasodilatory, spasmolytic, antiarrhythmic and gastrocytoprotective effects. The gastrocytoprotective effect is particularly important.

    Fodder additive and a process for the preparation thereof
    9.
    发明公开
    Fodder additive and a process for the preparation thereof 失效
    FODDER添加剂及其制备方法

    公开(公告)号：EP0179662A3

    公开(公告)日：1987-01-14

    申请号：EP85307686

    申请日：1985-10-24

    申请人： RICHTER GEDEON VEGYESZETI GYAR R.T.

    发明人： Perjes, Istvan ,  Selmeczi, Andras ,  Klebovich, Imre ,  Hajos, Gyorgy ,  Simon, Ferenc ,  Misley, Atilla ,  Szporny, Laszlo ,  Vereczkey, Laszlo ,  Toth, Edit ,  Torley, Jozsef ,  Sarkozy, Peter

    IPC分类号： A23K01/16

    CPC分类号： A23K50/30 ,  A23K20/111

    摘要： The invention relates to fodder additives comprising a compound inducing the microsomal enzyme system of the liver, such as a compound of the formula (I) wherein
    R i , R 2 and R 3 which may be the same or different represent hydrogen, halogen, trihalomethyl, or alkyl or alkoxy group each containing from 1 to 6 carbon atoms; R 4 is phenyl, dialkylaminocarbonyl or alkoxycarbonyl having from 1 to 6 carbon atoms in the alkyl and alkoxy moieties, respectively; R 5 is hydrogen or methyl, or together with R 4 and the nitrogen atom to which they are attached forms a heterocyclic ring having up to 8 members; n is an integer 1, 2, 3, 4 or 5; m is 0 or 1; a is 0 or 1,
    with the proviso that if a = 0, R 1 is trihalomethyl and R 2 and R 3 both are hydrogen. The compounds are preferably used in amount of 0.5 to 99% by weight, in admixture with a conventional carrier and/or additive and optionally at least one further active ingredient conventionally used in the animal husbandry. The enzyme-inducing compounds used according to the invention accelerate the elimination of various xenobiotics metabolizing in the iiver.

    Novel acrylic amide derivatives, a process for their preparation, pharmaceutical compositions containing the same and their use in medicine
    10.
    发明公开
    Novel acrylic amide derivatives, a process for their preparation, pharmaceutical compositions containing the same and their use in medicine 失效
    丙烯酰胺衍生物，它们的制备方法，含有它们和它们在医学中使用的药物组合物。

    公开(公告)号：EP0408106A2

    公开(公告)日：1991-01-16

    申请号：EP90201742.5

    申请日：1990-06-29

    申请人： RICHTER GEDEON VEGYESZETI GYAR R.T.

    发明人： Fodor, Tamas ,  Fischer, Janos ,  Dobay, Laszlo ,  Ezer, Elemér ,  Matuz, Judit ,  Saghy, Katalin ,  Szporny, Laszlo ,  Hajos, György

    IPC分类号： C07C323/60 ,  C07C317/24 ,  A61K31/10 ,  C07C315/04 ,  C07C319/20 ,  C07D295/18 ,  C07D277/06

    CPC分类号： C07D295/185 ,  C07C317/44 ,  C07C323/54 ,  C07D207/16

    摘要： Novel acrylic amide derivative of the formula
    wherein
    R¹ represents a hydrogen or a halogen atom or a C₁₋₄alkyl, a C₁₋₄alkoxy or a nitro group.
    n is an integer of 0 to 2,
    A represents an amino acid residue derived from a naturally occuring amino acid or an antipode there­of which is connected to the acrylic acyl residue through its amino group; or a residue derived from thiazolidinecarboxylic acid connected to the acrylic acyl group through its nitrogen, or a derivative of the above residues wherein any free carboxy group is esterified with a C₁₋₄alkyl group or is amidated; or A represents a group of formula
    wherein
    R₂ is a hydrogen atom or a phenyl, a C₁₋₄alkyl or a C₁₋₄alkoxycarbonyl group,
    and their salts which have interesting cytoprotective and antiulcer activities are provided. A process is also described for the preparation of said compounds.

    摘要翻译： 式 worin的R新颖丙烯酰胺衍生物<1> darstellt氢或卤素原子或C 1-4烷基，C 1-4烷氧基一个或硝基。 n是0〜2的整数，在氨基酸残基甲darstellt从天然存在的氨基酸或在它们的对映体的所有其连接到通过其氨基团的丙烯酸酰基残基衍生的; 或通过其氮连接到所述丙烯酸类酰基噻唑烷羧酸的残基，或上述残基的衍生物worin任何游离羧基被酯化被C 1-4烷基或酰胺化; 或甲darstellt式的基团的worin R2是氢原子或苯基，C 1-4烷基或一组C1-4alkoxycarbonyl，并且提供它们的盐其中具有令人感兴趣的细胞保护和抗溃疡活性。 因此，一个过程被描述为所述化合物的制备。