发明公开
EP0183352A2 Use of suramin for clinical treatment of infection with any of the members of the family of human-t-cell leukemia (htvl) viruses including lymphadenopathy virus (lav)
失效
使用苏拉明与家人的人T-Zelleukämie-（HTLV）病毒，包括Lymphadenopathievirus（LAV）的任何成员的临床治疗感染。
- 专利标题： Use of suramin for clinical treatment of infection with any of the members of the family of human-t-cell leukemia (htvl) viruses including lymphadenopathy virus (lav)
- 专利标题（中）： 使用苏拉明与家人的人T-Zelleukämie-（HTLV）病毒，包括Lymphadenopathievirus（LAV）的任何成员的临床治疗感染。
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申请号： EP85306913.6申请日： 1985-09-27
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公开(公告)号： EP0183352A2公开(公告)日： 1986-06-04
- 发明人: Yarchoan, Robert , Broder, Samuel , Gallo, Robert C. , Mitsuya, Hiroaki , Popovic, Mikulas
- 申请人： THE UNITED STATES OF AMERICA as represented by the Secretary United States Department of Commerce
- 申请人地址： National Technical Information Service, Office of Government Inventions and Patents, 5285 Port Royal Road Springfield, Virginia 22161 US
- 专利权人： THE UNITED STATES OF AMERICA as represented by the Secretary United States Department of Commerce
- 当前专利权人： THE UNITED STATES OF AMERICA as represented by the Secretary United States Department of Commerce
- 当前专利权人地址： National Technical Information Service, Office of Government Inventions and Patents, 5285 Port Royal Road Springfield, Virginia 22161 US
- 代理机构： Daley, Michael John
- 优先权： US660137 19841012
- 主分类号： A61K31/185
- IPC分类号： A61K31/185
摘要：
The present invention is a method for clinical or therapeutic treatment for the relief of illnesses caused by human T cell leukemia virus (HTLV) such as acquired immune deficiency syndrome (AIDS), pre-AIDS (lymphadenopathy syndrome), Kaposi's sarcoma, and human T cell leukemia-lymphoma by the administration of Suramin, preferably by the intravenous administration of Suramin. A concentration of Suramin of 50 µ g/ml or greater has been found effective in vitro and a therapeutic range of 50-340 µ g/ml is clinically attainable. A preferred course of intravenous treatment for about six weeks of Suramin giving .2 g at 0 day followed by 1 gram at Days 3, 7, 14, 21, 28 and 35 is utilized.
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