发明公开
- 专利标题： Process for the preparation of crystalline ceftanidime pentahydrate
- 专利标题（中）： 制备结晶碳酸二戊酯的方法
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申请号： EP85308016申请日： 1985-11-05
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公开(公告)号： EP0187450A3公开(公告)日： 1987-08-12
- 发明人: Browning, Ronald Clay , Pleiss, Melvin Gale, Jr.
- 申请人： ELI LILLY AND COMPANY
- 专利权人： ELI LILLY AND COMPANY
- 当前专利权人： ELI LILLY AND COMPANY
- 优先权： US669482 19841108
- 主分类号： C07D501/46
- IPC分类号： C07D501/46
摘要：
a Ceftazidime pentahydrate is obtained in purified crystalline form in a process comprising acidification of an aqueous solution of ceftazidime to about the optimum pH for nucleation of between about 4.0 and about 4.7 and maintenance at the optimum pH during crystallization. The crystalline product obtained exhibits enhanced stability toward polymer formation when stressed.
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