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公开(公告)号：EP0187450A3
公开(公告)日：1987-08-12
申请号：EP85308016
申请日：1985-11-05
IPC分类号： C07D501/46
CPC分类号： C07D501/46 , C07D501/12
摘要： a Ceftazidime pentahydrate is obtained in purified crystalline form in a process comprising acidification of an aqueous solution of ceftazidime to about the optimum pH for nucleation of between about 4.0 and about 4.7 and maintenance at the optimum pH during crystallization. The crystalline product obtained exhibits enhanced stability toward polymer formation when stressed.
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2.发明公开Process for the preparation of crystalline ceftazidime pentahydrate 失效头发头孢他啶五水合物维他命Zur Herstellung von kristallinischem
公开(公告)号：EP0187450A2
公开(公告)日：1986-07-16
申请号：EP85308016.6
申请日：1985-11-05
IPC分类号： C07D501/46
CPC分类号： C07D501/46 , C07D501/12
摘要： a Ceftazidime pentahydrate is obtained in purified crystalline form in a process comprising acidification of an aqueous solution of ceftazidime to about the optimum pH for nucleation of between about 4.0 and about 4.7 and maintenance at the optimum pH during crystallization. The crystalline product obtained exhibits enhanced stability toward polymer formation when stressed.
摘要翻译： 头孢他啶五水合物以纯化结晶形式获得，包括将头孢他啶水溶液酸化至约4.0至约4.7之间的成核的最佳pH，并在结晶期间以最佳pH维持。 获得的结晶产品在应力时表现出对聚合物形成的稳定性。
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公开(公告)号：EP0187450B1
公开(公告)日：1991-01-30
申请号：EP85308016.6
申请日：1985-11-05
IPC分类号： C07D501/46
CPC分类号： C07D501/46 , C07D501/12
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