发明公开
EP0187977A1 Tetrahydroquinoline derivatives, process for preparing the same and anti-peptic ulcer compositions containg the same
失效
四氢chin啉衍生物，Verfahren zu deren Herstellung und diese enthaltendeAntimagengeschwürzusammensetzungen。
- 专利标题： Tetrahydroquinoline derivatives, process for preparing the same and anti-peptic ulcer compositions containg the same
- 专利标题（中）： 四氢chin啉衍生物，Verfahren zu deren Herstellung und diese enthaltendeAntimagengeschwürzusammensetzungen。
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申请号： EP85116072.1申请日： 1985-12-17
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公开(公告)号： EP0187977A1公开(公告)日： 1986-07-23
- 发明人: Uchida, Minoru , Morita, Seiji , Chihiro, Masatoshi , Nakagawa, Kazuyuki
- 申请人： OTSUKA PHARMACEUTICAL CO., LTD.
- 申请人地址： 9, Kandatsukasa-cho 2-chome Chiyoda-ku Tokyo 101 JP
- 专利权人： OTSUKA PHARMACEUTICAL CO., LTD.
- 当前专利权人： OTSUKA PHARMACEUTICAL CO., LTD.
- 当前专利权人地址： 9, Kandatsukasa-cho 2-chome Chiyoda-ku Tokyo 101 JP
- 代理机构： Lehn, Werner, Dipl.-Ing.
- 优先权： JP267061/84 19841218; JP271433/84 19841221; JP145654/85 19850702; JP154708/85 19850712; JP252489/85 19851111
- 主分类号： C07D401/12
- IPC分类号： C07D401/12 ; C07D471/04 ; A61K31/47 ; A61K31/415 ; A61K31/435
摘要：
(a) Tetrahydroquinoline derivatives and salts thereof represented by the formula,
(wherein R 1a and R 2a are the same or different from each other, and are each hydrogen, halogen, hydroxy, alkyl, afkoxy. alkenyloxy, alkynyloxy or alkoxy-alkoxy; R 3a and R 4a are the same or different from each other, and are each hydrogen, a halogen, alkyl having to 3 halogen atoms as the substituents alkoxy, alkyl, nitro or alkanoyl; ( is 0 or 1; and
(b) imidazopyndme derivatives and salts thereof represented by the formula,
(wherein any one of Z and Y is -CH=, then the other one is a nitrogen; R 1b and R 2b are the same or different from each other, and are each hydrogen, alkoxycarbonyl, halogen, alkyl, amino or hydroxy; R 3b , R 4b and f 5b are the same or different from each other, and are each hydrogen, alkoxy or alkyl; A is alkylene group; ( is 0 or 1; provided that when Y is -CH=, Z is a nitrogen atom, and ( is 0, then R 3b , R 4b and R 5b should not be hydrogen at the same time) both having excellent anti-peptic ulcer activities, and are useful as treating agents for peptic ulcers such as gastric ulcer, duodenum ulcer and the like.
(wherein R 1a and R 2a are the same or different from each other, and are each hydrogen, halogen, hydroxy, alkyl, afkoxy. alkenyloxy, alkynyloxy or alkoxy-alkoxy; R 3a and R 4a are the same or different from each other, and are each hydrogen, a halogen, alkyl having to 3 halogen atoms as the substituents alkoxy, alkyl, nitro or alkanoyl; ( is 0 or 1; and
(b) imidazopyndme derivatives and salts thereof represented by the formula,
(wherein any one of Z and Y is -CH=, then the other one is a nitrogen; R 1b and R 2b are the same or different from each other, and are each hydrogen, alkoxycarbonyl, halogen, alkyl, amino or hydroxy; R 3b , R 4b and f 5b are the same or different from each other, and are each hydrogen, alkoxy or alkyl; A is alkylene group; ( is 0 or 1; provided that when Y is -CH=, Z is a nitrogen atom, and ( is 0, then R 3b , R 4b and R 5b should not be hydrogen at the same time) both having excellent anti-peptic ulcer activities, and are useful as treating agents for peptic ulcers such as gastric ulcer, duodenum ulcer and the like.
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