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22 条记录 (耗时 0.014 秒)

    Antimicrobial 1-substituted Phenyl-4-oxoquinoline-3-carboxylic acid compounds
    2.
    发明公开
    Antimicrobial 1-substituted Phenyl-4-oxoquinoline-3-carboxylic acid compounds 失效
    1-取代苯基-4-氧代羰基-3-羰基 - 维生素。

    公开(公告)号：EP0181521A1

    公开(公告)日：1986-05-21

    申请号：EP85113203.5

    申请日：1985-10-17

    申请人： OTSUKA PHARMACEUTICAL CO., LTD.

    发明人： Tone, Hitoshi ,  Miyamoto, Hisashi ,  Ueda, Hiraki ,  Nakagawa, Kazuyuki

    IPC分类号： C07D215/56 ,  C07D487/04 ,  A61K31/495

    CPC分类号： C07D215/56 ,  C07D487/04

    摘要： Novel compounds of the formula:


    wherein R 1 is a group of the formula:

    (where R 3 is hydrogen atom or an alkyl having 1 to 2 carbon atoms), or a group for the formula:

    R 2 is a group of the formula:

    R 4 is hydroxy, fluorine atom or an alkanoyloxy having 1 to 6 carbon atoms, R 5 is hydrogen or fluorine atom, and X is hydrogen or fluorine atom, provided that when R 1 is

    and X is hydrogen atom, R 2 is not a group of the formula

    and pharmaceutically acceptable salts thereof, said compounds having excellent antimicrobial activity and hence being useful as an antimicrobial agent, and a pharmaceutical composition comprising as an active ingredient said compounds or a salt thereof in admixture with a pharmaceutically acceptable diluent or carrier.

    摘要翻译： 下式的新型化合物：其中R 1为下式基团：其中R 3为氢原子或具有1至2个碳原子的烷基;或式 ： R 2是下式的基团： R 4是羟基，氟原子或具有1至6个碳原子的烷酰氧基，R 5是氢或氟原子，X是 氢或氟原子，条件是当R 1是而X是氢原子时，R 2不是式的基团及其药学上可接受的盐，所述化合物具有优异的抗微生物活性，因此 可用作抗微生物剂，以及包含作为活性成分的药物组合物，所述化合物或其盐与药学上可接受的稀释剂或载体混合。

    Novel oxindole derivative
    4.
    发明公开
    Novel oxindole derivative 失效
    新的氧化物衍生物

    公开(公告)号：EP0126635A3

    公开(公告)日：1987-09-09

    申请号：EP84303381

    申请日：1984-05-17

    申请人： OTSUKA PHARMACEUTICAL CO., LTD.

    发明人： Uchida, Minoru ,  Komatsu, Makoto ,  Nakagawa, Kazuyuki

    IPC分类号： C07D209/34 ,  A61K31/405

    CPC分类号： C07D209/34 ,  C07D209/20

    摘要： Novel oxindole derivative and salt thereof represented by the general formula,
    wherein R' is a hydrogen atom, a lower alkyl group, a lower alkenyl group, a lower alkynyl group or a phenyl-lower alkyl group; R 2 is a hydrogen atom or a lower alkyl group; R 3 is a hydrogen atom, a cycloalkylcarbonyl group, a benzoyl group which may have 1 to 3 substituents selected from the group consisting of a halogen atom, a lower alkyl group and a lower alkoxy group on the phenyl ring, or a phenyl-lower alkanoyl group which may have halogen atoms as the substituents on the phenyl ring; provided that when R 4 is a hydrogen atom, then R 3 should be neither a hydrogen atom nor a lower alkyl group. The novel oxindole derivative and salt thereof possesses anti-peptic ulcer effects and are useful as anti-peptic ulcer agents.

    Tetrahydroquinoline derivatives, process for preparing the same and anti-peptic ulcer compositions containg the same
    5.
    发明公开
    Tetrahydroquinoline derivatives, process for preparing the same and anti-peptic ulcer compositions containg the same 失效
    四氢chin啉衍生物，Verfahren zu deren Herstellung und diese enthaltendeAntimagengeschwürzusammensetzungen。

    公开(公告)号：EP0187977A1

    公开(公告)日：1986-07-23

    申请号：EP85116072.1

    申请日：1985-12-17

    申请人： OTSUKA PHARMACEUTICAL CO., LTD.

    发明人： Uchida, Minoru ,  Morita, Seiji ,  Chihiro, Masatoshi ,  Nakagawa, Kazuyuki

    IPC分类号： C07D401/12 ,  C07D471/04 ,  A61K31/47 ,  A61K31/415 ,  A61K31/435

    CPC分类号： C07D213/80 ,  C07D215/04 ,  C07D215/233 ,  C07D215/26 ,  C07D215/60 ,  C07D401/12 ,  C07D471/04

    摘要： (a) Tetrahydroquinoline derivatives and salts thereof represented by the formula,
    (wherein R 1a and R 2a are the same or different from each other, and are each hydrogen, halogen, hydroxy, alkyl, afkoxy. alkenyloxy, alkynyloxy or alkoxy-alkoxy; R 3a and R 4a are the same or different from each other, and are each hydrogen, a halogen, alkyl having to 3 halogen atoms as the substituents alkoxy, alkyl, nitro or alkanoyl; ( is 0 or 1; and
    (b) imidazopyndme derivatives and salts thereof represented by the formula,
    (wherein any one of Z and Y is -CH=, then the other one is a nitrogen; R 1b and R 2b are the same or different from each other, and are each hydrogen, alkoxycarbonyl, halogen, alkyl, amino or hydroxy; R 3b , R 4b and f 5b are the same or different from each other, and are each hydrogen, alkoxy or alkyl; A is alkylene group; ( is 0 or 1; provided that when Y is -CH=, Z is a nitrogen atom, and ( is 0, then R 3b , R 4b and R 5b should not be hydrogen at the same time) both having excellent anti-peptic ulcer activities, and are useful as treating agents for peptic ulcers such as gastric ulcer, duodenum ulcer and the like.

    摘要翻译： （a）由下式表示的四氢喹啉衍生物及其盐：其中R 1a和R 2a彼此相同或不同，分别为氢，卤素，羟基，烷基， 烷氧基，烯氧基，炔氧基或烷氧基 - 烷氧基; R 3a和R 4a彼此相同或不同，并且各自为氢，卤素，具有1-3个卤素原子作为取代基的烷基，烷基， 硝基或烷酰基; l为0或1;和b）由下式表示的咪唑并吡啶衍生物及其盐，其中Z和Y中的任一个为-CH =，则另一个为硝基; R 1b和R 2b彼此相同或不同，并且各自为氢，烷氧基 - 羰基，卤素，烷基，氨基或羟基; R 3b，R 4b和R 5b为 相同或不同，各自为氢，烷氧基或烷基; A为亚烷基; l为0或1;条件是当Y为-CH =时，Z为氮原子，l为0，则R 3b，R 4b和R 5b不应该是b e氢）同时具有优异的抗消化性溃疡活性，并且可用作胃溃疡，十二指肠溃疡等消化性溃疡的治疗剂。