发明公开
EP0187991A2 Antitumor active substance, process for preparing the same, drug containing the substance, gene coding for the substance, vector containing the gene and recombinant microorganism
失效
具有抗肿瘤活性的物质,其制备方法,含有药物物质的,编码该物质的基因,该含基因的载体和重组微生物。
- 专利标题: Antitumor active substance, process for preparing the same, drug containing the substance, gene coding for the substance, vector containing the gene and recombinant microorganism
- 专利标题(中): 具有抗肿瘤活性的物质,其制备方法,含有药物物质的,编码该物质的基因,该含基因的载体和重组微生物。
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申请号: EP85116344.4申请日: 1985-12-20
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公开(公告)号: EP0187991A2公开(公告)日: 1986-07-23
- 发明人: Nakai, Satoru , Kaneta, Mayumi , Kikumoto, Yoshikazu , Hong, Yeong-Man , Kawai, Kazuyoshi Shinsei Bld. 301 , Takegata, Setsuko , Ishii, Kiyoshi , Yanagihara, Yasuo , Hirai, Yoshikatsu
- 申请人: OTSUKA PHARMACEUTICAL CO., LTD.
- 申请人地址: 9, Kandatsukasa-cho 2-chome Chiyoda-ku Tokyo 101 JP
- 专利权人: OTSUKA PHARMACEUTICAL CO., LTD.
- 当前专利权人: OTSUKA PHARMACEUTICAL CO., LTD.
- 当前专利权人地址: 9, Kandatsukasa-cho 2-chome Chiyoda-ku Tokyo 101 JP
- 代理机构: VOSSIUS & PARTNER
- 优先权: JP271207/84 19841221; JP138280/85 19850624; JP138281/85 19850624; JP220882/85 19851003; JP283238/85 19851216
- 主分类号: C07K15/00
- IPC分类号: C07K15/00 ; C12N15/25
摘要:
This invention provides an antitumor active substance GIF, a process for preparing the same, an antitumor composition containing the substance, a gene coding for GIF, a vector containing the gene and a recombinant microorganism, the substance GIF comprises as its component protein polypeptide A of the following primary structure. Trp Tyr lie Ser Thr Ser Gin Ala Glu Asn Met Pro Val Phe Leu Gly Gly Thr Lys Gly Gly Gin Asp lie Thr Asp Phe Thr Met Gln Phe Val Ser Ser OH wherein X is Cys or Ser and Z is H or a peptide represented by the amino acid sequence or a peptide having the above sequence wherein at least one amino acid is removed from the N terminal or an amino acid.
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