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79 条记录 (耗时 0.021 秒)

    THE IL-1L1 GENE AND POLYPEPTIDE PRODUCTS
    1.
    发明公开
    THE IL-1L1 GENE AND POLYPEPTIDE PRODUCTS 审中-公开
    与IL-1L1基因和多肽产品

    公开(公告)号：EP1200593A2

    公开(公告)日：2002-05-02

    申请号：EP00948733.1

    申请日：2000-07-17

    申请人： Interleukin Genetics, Inc.

    发明人： NICKLIN, Martin ,  BARTON, Jenny

    IPC分类号： C12N15/25 ,  C07K14/545

    CPC分类号： C07K14/545

    摘要： The present invention relates to the discovery of novel genes encoded by the interleukin-1 locus. The IL-1L1 gene is located in the interval between the IL-1Beta and IL-1 receptor antagonist encoding genes and encodes a polypeptide which is homologous to both IL-1 agonist and IL-1 antagonist proteins. Therapeutics, diagnostics and screening assays based on these molecules are also disclosed.

    IL-1 RELATED POLYPEPTIDES
    2.
    发明公开
    IL-1 RELATED POLYPEPTIDES 审中-公开
    IL-1相关多肽

    公开(公告)号：EP1141299A2

    公开(公告)日：2001-10-10

    申请号：EP99968539.9

    申请日：1999-12-22

    申请人： Genentech, Inc.

    发明人： GODDARD, Audrey ,  PAN, James

    IPC分类号： C12N15/25 ,  C07K14/545 ,  C12N15/63 ,  C12N5/10 ,  C07K19/00 ,  C07K16/24

    CPC分类号： C07K14/545 ,  C07K2319/00

    摘要： The present invention is directed to novel polypeptides having homology to the IL-1-like family of proteins and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention, and methods for producing the polypeptides of the present invention.

    METHOD OF PRODUCING PERMUTEINS BY SCANNING PERMUTAGENESIS
    3.
    发明公开
    METHOD OF PRODUCING PERMUTEINS BY SCANNING PERMUTAGENESIS 审中-公开
    通过扫描增殖生成生产青蒿素的方法

    公开(公告)号：EP1115854A1

    公开(公告)日：2001-07-18

    申请号：EP99949630.0

    申请日：1999-09-24

    申请人： G.D. SEARLE & CO.

    发明人： LEE, Stephen, C.

    IPC分类号： C12N15/10 ,  C12N15/25 ,  C12N15/62 ,  C07K14/535 ,  C07K14/005

    CPC分类号： C40B40/02 ,  C07K14/535 ,  C07K2319/00 ,  C12N15/102 ,  C12N15/1037

    摘要： A method of producing circularly-permuted proteins (permuteins) by scanning permutagenesis comprises making and inserting a series of circularly-permuted genes into a display vector, expressing these genes such that the gene products are localized to the surface of the display vector, generating a library of display vectors presenting the permuted protein, affinity-selecting the display vectors with a target protein that can bind the permuted protein, isolating and analyzing clones of selected display vectors to identify the circularly-permuted protein. The invention further discloses methods of expressing and uses of permuteins.

    摘要翻译： 通过扫描置换（permutagenesis）产生循环置换的蛋白质（permutein）的方法包括制造一系列循环置换的基因并将其插入到展示载体中，表达这些基因使得基因产物定位于展示载体的表面，产生 呈递改变的蛋白质的展示载体文库，用可与改变的蛋白质结合的目标蛋白质亲和选择展示载体，分离和分析选择的展示载体的克隆以鉴定循环改变的蛋白质。 本发明进一步公开了permutein的表达和用途的方法。

    Polypeptide and uses thereof
    4.
    发明公开
    Polypeptide and uses thereof 审中-公开
    多肽及其用途

    公开(公告)号：EP1092773A2

    公开(公告)日：2001-04-18

    申请号：EP00308948.9

    申请日：2000-10-11

    申请人： KABUSHIKI KAISHA HAYASHIBARA SEIBUTSU KAGAKU KENKYUJO

    发明人： Ushio, Shimpei ,  Nukada, Yoshiyuki ,  Yamamoto, Kozo ,  Kurimoto, Masashi

    IPC分类号： C12N15/25 ,  C07K14/545 ,  C12N15/63 ,  C12N5/10 ,  C07K16/24 ,  A61K38/20 ,  A61K39/395

    CPC分类号： C07K16/244 ,  A61K38/00 ,  C07K14/54

    摘要： Disclosed are a polypeptide comprising the amino acid sequence of SEQ ID NO:5 or an amino acid sequence which has a homology of at least 75% with respect to the amino acid sequence of SEQ ID NO:5 and contains the amino acid sequence of SEQ ID NO:7 as an internal partial amino acid sequence; a DNA comprising either a nucleotide sequence which has the nucleotide sequence of SEQ ID NO:4, a nucleotide sequence which has a homology of at least 75% with respect to the nucleotide sequence of SEQ ID NO:4 and contains the nucleotide sequence of SEQ ID NO:8 at the 5'-terminus, or a complementary nucleotide sequence thereunto; an antibody which immunologically reacts with the polypeptide; and a method for detecting the polypeptide.

    摘要翻译： 公开了包含SEQ ID NO：5的氨基酸序列或与SEQ ID NO：5的氨基酸序列具有至少75％同源性并且含有SEQ ID NO：5的氨基酸序列的氨基酸序列的多肽 ID NO：7作为内部部分氨基酸序列; 包含具有SEQ ID NO：4的核苷酸序列的核苷酸序列，与SEQ ID NO：4的核苷酸序列具有至少75％同源性且含有SEQ ID NO：4的核苷酸序列的核苷酸序列的DNA 在5'末端的ID NO：8或其互补核苷酸序列; 与多肽发生免疫反应的抗体; 和检测多肽的方法。

    Antitumor active substance, process for preparing the same, drug containing the substance, gene coding for the substance, vector containing the gene and recombinant microorganism
    8.
    发明授权
    Antitumor active substance, process for preparing the same, drug containing the substance, gene coding for the substance, vector containing the gene and recombinant microorganism 失效
    抗菌活性物质，其制备方法，含有物质的药物，物质的基因编码，含有基因的载体和重组微生物

    公开(公告)号：EP0187991B1

    公开(公告)日：1992-05-13

    申请号：EP85116344.4

    申请日：1985-12-20

    申请人： OTSUKA PHARMACEUTICAL CO., LTD.

    发明人： Nakai, Satoru ,  Kaneta, Mayumi ,  Kikumoto, Yoshikazu ,  Hong, Yeong-Man ,  Kawai, Kazuyoshi Shinsei Bld. 301 ,  Takegata, Setsuko ,  Ishii, Kiyoshi ,  Yanagihara, Yasuo ,  Hirai, Yoshikatsu

    IPC分类号： C07K15/00 ,  C12N15/25

    CPC分类号： C07K14/545 ,  A61K38/00 ,  Y02A50/473

    摘要： This invention provides an antitumor active substance GIF, a process for preparing the same, an antitumor composition containing the substance, a gene coding for GIF, a vector containing the gene and a recombinant microorganism, the substance GIF comprises as its component protein polypeptide A of the following primary structure. Z Ala Pro Val Arg Ser Leu Asn Cys Thr Leu Arg Asp Ser Gln Gln Lys Ser Leu Val Met Ser Gly Pro Tyr Glu Leu Lys Ala Leu His Leu Gln Gly Gln Asp Met Glu Gln Gln Val Val Phe Ser Met Ser Phe Val Gin Gly Glu Glu Ser Asn Asp Lys Ile Pro Val Ala Leu Gly Leu Lys Glu Lys Asn Leu Tyr Leu Ser X Val Leu Lys Asp Asp Lys Pro Thr Leu Gln Leu Glu Ser Val Asp Pro Lys Asn Tyr Pro Lys Lys Lys Met Glu Lys Arg Phe Val Phe Asn Lys Ile Glu Ile Asn Asn Lys Leu Glu Phe Glu Ser Ala Gln Phe Pro Asn Trp Tyr Ile Ser Thr Ser Gln Ala Glu Asn Met Pro Val Phe Leu Gly Gly Thr Lys Gly Gly Gln Asp Ile Thr Asp Phe Thr Met Gln Phe Val Ser Ser OH wherein X is Cys or Ser and Z is H or a peptide represented by the amino acid sequence Met Lys Cys Ser Phe Gln Asp Leu Asp Leu Cys Pro Leu Asp Gly Gly Ile Gln Leu Arg Ile Ser Asp His His Tyr Ser Lys Gly Phe Arg Gln Ala Ala Ser Val Val Val Ala Met Asp Lys Leu Arg Lys Met Leu Val Pro Cys Pro Gln Thr Phe Gln Glu Asn Asp Leu Ser Thr Phe Phe Pro Phe Ile Phe Glu Glu Glu Pro Ile Phe Phe Asp Thr Trp Asp Asn Glu Ala Tyr Val His Asp or a peptide having the above sequence wherein at least one amino acid is removed from the N terminal or an amino acid.