发明公开
EP0191375A2 7-n-aminomethylenemitomycin derivatives, process for production thereof and anti-tumor composition
失效
7-N-氨基亚甲基螺旋霉素，Verfahren zu ihrer Herstellung und Antitumorzubereitung。
- 专利标题： 7-n-aminomethylenemitomycin derivatives, process for production thereof and anti-tumor composition
- 专利标题（中）： 7-N-氨基亚甲基螺旋霉素，Verfahren zu ihrer Herstellung und Antitumorzubereitung。
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申请号： EP86101214.4申请日： 1986-01-30
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公开(公告)号： EP0191375A2公开(公告)日： 1986-08-20
- 发明人: Shirahata, Kunikatsu , Kono, Motomichi , Kasai, Masaji , Ashizawa, Tadashi
- 申请人： KYOWA HAKKO KOGYO CO., LTD.
- 申请人地址： 6-1, Ohte-Machi Itchome Chiyoda-ku, Tokyo JP
- 专利权人： KYOWA HAKKO KOGYO CO., LTD.
- 当前专利权人： KYOWA HAKKO KOGYO CO., LTD.
- 当前专利权人地址： 6-1, Ohte-Machi Itchome Chiyoda-ku, Tokyo JP
- 代理机构： Casalonga, Axel
- 优先权： JP17532/85 19850131
- 主分类号： C07D487/14
- IPC分类号： C07D487/14 ; A61K31/40
摘要：
Mitomycin derivatives represented by the formula (I):
wherein R 1 and R 2 may be the same or different, and represent a hydrogen atom or a lower alkyl group: R 3 and R 4 mean that when R 3 is a hydrogen atom, R 4 represents -CH 2 0CONH 2 or
(wherein R 1 and R 2 have the same significances as defined above), or R 3 and R 4 are combined to form =CH 2 ; Y and Z may be the same or different, and represent a hydrogen atom for a methyl group; represents a- or β-bond, provided that
Y represents a hydrogen atom when R 4 takes β-conflguration, have an excellent antitumor activity.
wherein R 1 and R 2 may be the same or different, and represent a hydrogen atom or a lower alkyl group: R 3 and R 4 mean that when R 3 is a hydrogen atom, R 4 represents -CH 2 0CONH 2 or
(wherein R 1 and R 2 have the same significances as defined above), or R 3 and R 4 are combined to form =CH 2 ; Y and Z may be the same or different, and represent a hydrogen atom for a methyl group; represents a- or β-bond, provided that
Y represents a hydrogen atom when R 4 takes β-conflguration, have an excellent antitumor activity.
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