发明公开
- 专利标题： HEPATITIS A VIRUS PURIFIED AND TRIPLY CLONED
- 专利标题（中）： 纯化的A型肝炎病毒，三克隆。
-
申请号： EP85904746.0申请日： 1985-09-18
-
公开(公告)号： EP0196316A1公开(公告)日： 1986-10-08
- 发明人: DAEMER, Richard, J. , FEINSTONE, Stephen, M. , GUST, Ian, D. , PURCELL, Robert, H.
- 申请人： THE UNITED STATES OF AMERICA represented by the Department of Commerce
- 申请人地址： National Technical Information Service Office of Federal Patent Licensing 5285 Port Royal Road Springfield, Virginia 22161 US
- 专利权人： THE UNITED STATES OF AMERICA represented by the Department of Commerce
- 当前专利权人： THE UNITED STATES OF AMERICA represented by the Department of Commerce
- 当前专利权人地址： National Technical Information Service Office of Federal Patent Licensing 5285 Port Royal Road Springfield, Virginia 22161 US
- 代理机构： Daley, Michael John, et al
- 优先权： US19840652067 19840919
- 国际公布： WO1986001826 19860327
- 主分类号： A61K39
- IPC分类号： A61K39 ; C12N7
摘要：
Human hepatitis A virus (HAV) can be purified by a process in which master seed lots of HM-175 strain of hepatitis A virus are prepared from triply cloned virus by terminal dilution at passage level about 20 or preferably at least 20-30. The clones tested induced minimal or no hepatitis although significant antibody response was provoked in inoculated primates. A method of preparing the triply cloned inoculum is also described.
信息查询
