发明公开
EP0200280A3 Oxidation resistant IL-2 muteins and their production, formulations containing such muteins, and DNA sequences and expression vectors coding for such muteins and corresponding transformed host cells
失效
耐氧化IL-2和它们的生产方法，含有此类制剂的制剂，以及DNA序列和表达载体的编码，用于这些宿主和相应的转化的宿主细胞
- 专利标题： Oxidation resistant IL-2 muteins and their production, formulations containing such muteins, and DNA sequences and expression vectors coding for such muteins and corresponding transformed host cells
- 专利标题（中）： 耐氧化IL-2和它们的生产方法，含有此类制剂的制剂，以及DNA序列和表达载体的编码，用于这些宿主和相应的转化的宿主细胞
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申请号： EP86200766申请日： 1986-01-17
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公开(公告)号： EP0200280A3公开(公告)日： 1988-08-24
- 发明人: Koths, Kirston Edward , Halenbeck, Robert Forgan , Innis, Michael Allan
- 申请人： CETUS CORPORATION
- 专利权人： CETUS CORPORATION
- 当前专利权人： CETUS CORPORATION
- 优先权： US692596 19850118; US810656 19851217
- 主分类号： C12N15/00
- IPC分类号： C12N15/00 ; C12P21/02 ; C07K13/00 ; A61K37/02
摘要：
A biologically active reference (e.g. human) IL-2 (interleukin-2) protein is protected against oxidation by a method involving substituting a conservative amino acid for each methionine residue susceptible to chloramine T or peroxide oxidation and wherein additional, non-susceptible methionine residues are not so substituted.
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