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公开(公告)号：EP1475440A3
公开(公告)日：2004-11-17
申请号：EP04076368.2
申请日：1994-01-12
CPC分类号： A61K49/0004 , A61K38/00 , C07K14/475
摘要： Growth differentiation factor-3 (GDF-3) is disclosed along with its polynucleotide sequence and ammo acid sequence. Also disclosed are diagnostic and therapeutic methods of using the GDF-3 polypeptide and polynucleotide sequences.
摘要翻译： 公开了生长分化因子-3（GDF-3）及其多核苷酸序列和氨基酸序列。 还公开了使用GDF-3多肽和多核苷酸序列的诊断和治疗方法。
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2.发明公开TRICYCLOPOLYAZAMACROCYCLOPHOSPHONIC ACIDS, COMPLEXES AND DERIVATIVES THEREOF, FOR USE AS CONTRAST AGENTS 失效三环氧杂环戊烷环磷酸，它们的配合物和衍生物，用作对比剂
公开(公告)号：EP0697872A4
公开(公告)日：2003-04-02
申请号：EP94916043
申请日：1994-05-06
发明人： KIEFER GARRY E
IPC分类号： A61K49/00 , C07D471/18 , C07D471/22 , C07F9/6561 , G01R33/28 , A61K31/44 , A61K31/675 , A61K51/04 , C07F9/30 , C07F9/38 , C07F9/40 , G01N24/08 , A61K49/06 , C07K13/00
CPC分类号： C07D471/18 , C07D471/22 , C07F9/6561 , G01R33/281
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3.发明公开TICK (IXODES SCAPULARIS) VECTOR SALIVA-INDUCED LYME DISEASE SPIROCHETE (BORRELIA BURGDORFERI) ANTIGENS AS VACCINE CANDIDATES 失效抗原作为疫苗候选人由蜱向量（肩突硬蜱）唾液致莱姆病螺旋体（莱姆病螺旋体）
公开(公告)号：EP0880543A4
公开(公告)日：2000-08-02
申请号：EP96939512
申请日：1996-10-28
发明人： NELSON DAVID R , MATHER THOMAS N , SCORPIO ANGELO
IPC分类号： A61K39/00 , C07K14/20 , C07K14/44 , C07K15/04 , A61K35/16 , C07H19/00 , C07H21/00 , C07K13/00 , C12P19/34 , C12Q1/00 , C12Q1/68
摘要： The invention relates to a method by which new antigens from vector-borne pathogens may be discovered and analyzed by incubating the viable pathogens in the saliva of their vector host. Three such antigens, proteins with the approximate molecular weights of 19, 22 and 24 kDa, have been discovered and analyzed from a strain of B. burgdorferi T-15. The proteins provide a route for the development of immunodiagnostics for Lyme disease and related disorders. The proteins and related amino acids and DNA sequences may also be used for the immunization, for the detection of B. burgdorfei in human or body fluids, and also for the generation of specific antibodies for use in diagnosis, epidemiology, prevention of and treatment of Lyme disease.
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公开(公告)号：EP0630383A4
公开(公告)日：1998-04-22
申请号：EP93906174
申请日：1993-02-24
IPC分类号： A61K38/00 , A61K38/16 , A61K47/48 , A61P3/08 , A61P3/10 , C07K14/34 , C07K14/52 , C07K14/54 , C07K14/55 , C07K14/575 , C07K14/62 , C07K14/705 , C07K19/00 , C07K7/10 , A61K37/02 , A61K45/05 , C07K13/00
CPC分类号： C07K14/55 , A61K38/164 , A61K47/642 , C07K14/34 , C07K2319/55 , C07K2319/75 , Y10S514/866
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公开(公告)号：EP0615451A4
公开(公告)日：1997-04-23
申请号：EP93914117
申请日：1993-05-25
申请人： IMMUNEX CORP
IPC分类号： A61K38/00 , C07K14/705 , C07K16/00 , C07K16/28 , C12N15/19 , A61K35/14 , A61K37/00 , A61K37/36 , A61K39/00 , C07H21/04 , C07K13/00 , C07K15/00 , C12N15/00 , C12P21/06
CPC分类号： C07K16/2875 , A61K38/00 , C07K14/70575 , C07K14/70578 , C07K16/00 , C07K16/2878 , C07K2317/73 , C07K2317/74 , C07K2319/00 , C07K2319/036 , C07K2319/30 , C07K2319/32 , Y10S514/883
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6.发明公开ENZYMATICALLY-PRODUCED DIMERIC IL-2 AND A NERVE-DERIVED TRANSGLUTAMINASE ENZYME FOR ITS PREPARATION. 失效精制二甲基二异氰酸酯和神经衍生的转谷氨酰胺酶，用于其制备。
公开(公告)号：EP0610475A4
公开(公告)日：1997-04-23
申请号：EP93918528
申请日：1993-07-30
申请人： YEDA RES & DEV
发明人： SCHWARTZ MICHAL , EITAN SHOSHANA
IPC分类号： A61K38/00 , A61K38/45 , A61P25/00 , A61P25/28 , A61P27/02 , A61P43/00 , C07K1/22 , C07K7/06 , C07K7/08 , C07K14/00 , C07K14/52 , C07K14/54 , C07K14/55 , C07K16/00 , C12N9/10 , C12N15/09 , C12P21/02 , A01N37/18 , A61K31/00 , A61K37/00 , A61K37/52 , A61K37/56 , A61K37/58 , A61K37/60 , C07K3/00 , C07K13/00 , C07K15/00 , C07K17/00
CPC分类号： C12N9/1044 , A61K38/00 , C07K14/55
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7.发明公开Methods for regulating the immune response using CTLA4-binding molecules and IL4-binding molecules 失效一种用于调节通过使用CTLA4-结合分子和IL4结合分子的免疫应答的方法。
公开(公告)号：EP0613944A3
公开(公告)日：1997-03-05
申请号：EP94100882.3
申请日：1994-01-21
发明人： Linsley, Peter S. , Ledbetter, Jeffrey A. , Damle, Nitin K. , Brady, William , Wallace, Philip M.
CPC分类号： C07K16/2827 , A61K38/00 , C07K14/70521 , C07K14/7155 , C07K16/2818 , C07K2317/73 , C07K2319/02 , C07K2319/036 , C07K2319/30 , C07K2319/32 , Y10S424/81 , Y10S530/868
摘要： The invention identifies the CTLA4 receptor as a ligand for the B7 antigen. The complete amino acid sequence encoding human CTLA4 receptor gene is provided. Methods are provided for expressing CTLA4 as an immunoglobulin fusion protein, for preparing hybrid CTLA4 fusion proteins, and for using the soluble fusion proteins, fragments and derivatives thereof, including monoclonal antibodies reactive with B7 and CTLA4, to regulate T cell interactions and immune responses mediated by such interactions.
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公开(公告)号：EP0586687A4
公开(公告)日：1996-04-17
申请号：EP93908615
申请日：1993-03-25
申请人： UNIV NEW YORK
IPC分类号： A61K39/00 , C07H3/06 , C07H13/04 , C07H15/04 , C07H15/10 , C07K16/12 , C07K16/20 , C07K16/40 , C12N9/10 , C12N15/30 , C12P19/00 , C12P21/00 , A61K37/52 , A61K39/005 , A61K39/395 , C07H21/02 , C07H21/04 , C07K3/18 , C07K13/00 , C12N5/10 , C12Q1/48
CPC分类号： C07H13/04 , A61K39/00 , C07H3/06 , C07H15/04 , C07H15/10 , C07K16/12 , C07K16/20 , C07K16/40 , C12N9/1081 , C12P19/00 , C12P21/005
摘要： Polypeptides are provided having trans-sialidase enzymatic activity in substantially pure form, nucleic acids coding therefor, antibodies specific for such polypeptides, processes for producing the enzyme and methods of use of the enzyme, in particular for the synthesis of sialyl alpha (2->3)-linked saccharides, glycoproteins and glycolipids. Such enzymes are isolatable as nucleic acid or amino acid sequences from parasites of the genus Trypanosoma.
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9.发明公开Bone - associated transcription control factor-like protein and process for producing the same 失效骨 - 相关转录调控因子样蛋白及其生产方法。
公开(公告)号：EP0614974A3
公开(公告)日：1996-03-06
申请号：EP94102992.8
申请日：1994-02-28
CPC分类号： C07K14/51 , A61K38/00 , C07K14/4702 , C07K2319/02
摘要： Bone-associated proteins derived from bone of mammals including mice, human beings, named OSF-6. The protein is the novel natural type mammal protein which can play an important role in bone formation and belongs to a group of transcription control factors. OSF-6 can be used as a therapeutic agent for bone metabolic diseases and also as a diagnostic agent for bone metabolic diseases since it may demonstrate a high organ specificity to bone.
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公开(公告)号：EP0626805A4
公开(公告)日：1995-12-06
申请号：EP93904757
申请日：1993-01-28
发明人： KAPPLER JOHN W , MARRACK PHILIPPA
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