发明公开
EP0221346A1 (N-substituted-2-hydroxy) benzamides and N-substituted-2-hydroxy-alpha-oxo-benzeneacetamides and pharmaceutical compositions thereof having activity as modulators of the arachidonic acid cascade
失效
（N-取代的2-羟基）苯甲酰胺和N-取代的2-羟基-α-氧代benzenacetamide和具有活性Arachidonicsäure级联的调节剂及其药物组合物。
- 专利标题： (N-substituted-2-hydroxy) benzamides and N-substituted-2-hydroxy-alpha-oxo-benzeneacetamides and pharmaceutical compositions thereof having activity as modulators of the arachidonic acid cascade
- 专利标题（中）： （N-取代的2-羟基）苯甲酰胺和N-取代的2-羟基-α-氧代benzenacetamide和具有活性Arachidonicsäure级联的调节剂及其药物组合物。
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申请号： EP86113490.6申请日： 1986-10-01
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公开(公告)号： EP0221346A1公开(公告)日： 1987-05-13
- 发明人: Connor, David T. , Flynn, Daniel L. , Cetenko, Wiaczeslaw A. , Sircar, Jagadish C. , Schwender, Charles F. , Johnson, Elizabeth A. , Sorenson, Roderick J. , Unangst, Paul C.
- 申请人： WARNER-LAMBERT COMPANY
- 申请人地址： 201 Tabor Road Morris Plains New Jersey 07950 US
- 专利权人： WARNER-LAMBERT COMPANY
- 当前专利权人： WARNER-LAMBERT COMPANY
- 当前专利权人地址： 201 Tabor Road Morris Plains New Jersey 07950 US
- 代理机构： Mansmann, Ivo
- 优先权： US782763 19851001
- 主分类号： C07C235/38
- IPC分类号： C07C235/38 ; A61K31/165
摘要：
The present invention relates to N-substituted 2-hydroxybenzamide and N-substituted 2-hydroxy-α-oxo-benezene acetamide having the formula
wherein
y one or two is
R₁ and R₅ represent a hydrogen atom or a substituent
b is zero to four
and
R₆ is an alkyl group having 6 to 20 carbon atoms, an eventually substituted aryl or aralkyl group or a group CH=CHR₄ or (CH₂) n -CO-R₄ in which R₄ represents an eventually substituted phenyl group.
These compounds are usefull for the treatment of diseases in which products having lipoxygenase enzyme activity contribute to the pathological condition. Selected novel intermediates are also the present invention.
wherein
y one or two is
R₁ and R₅ represent a hydrogen atom or a substituent
b is zero to four
and
R₆ is an alkyl group having 6 to 20 carbon atoms, an eventually substituted aryl or aralkyl group or a group CH=CHR₄ or (CH₂) n -CO-R₄ in which R₄ represents an eventually substituted phenyl group.
These compounds are usefull for the treatment of diseases in which products having lipoxygenase enzyme activity contribute to the pathological condition. Selected novel intermediates are also the present invention.
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