发明公开
- 专利标题： Anti-human ovarian cancer immunotoxins and methods of use thereof
- 专利标题（中）： 抗人类癌免疫球蛋白及其使用方法
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申请号： EP86309516申请日： 1986-12-05
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公开(公告)号： EP0226419A3公开(公告)日： 1988-04-20
- 发明人: Bjorn, Michael Jon , Fitzgerald, David , Frankel, Arthur Edward , Laird, Walter Joseph , Pastan, Ira , Ring, David Barratt , Willingham, Mark , Winkelhake, Jeffrey
- 申请人： CETUS CORPORATION , THE GOVERNMENT OF THE UNITED STATES OF AMERICA as represented by the Secretary Department of Commerce
- 专利权人： CETUS CORPORATION,THE GOVERNMENT OF THE UNITED STATES OF AMERICA as represented by the Secretary Department of Commerce
- 当前专利权人： CETUS CORPORATION,THE GOVERNMENT OF THE UNITED STATES OF AMERICA as represented by the Secretary Department of Commerce
- 优先权： US806320 19851206
- 主分类号： A61K47/00
- IPC分类号： A61K47/00 ; A61K39/395 ; A61K37/02
摘要：
Immunotoxins comprising a cytotoxic moiety and monoclonal antibodies which bind to human ovarian cancer tissue having at least one of the following capabilities are claimed: cytotoxic ID 50 of 10 nM or less against human ovarian cancer cells, retardation of human ovarian cancer tumor growth in mammals or extension of survival of a mammal carrying a human ovarian cancer tumor. Antigens to which the monoclonal antibody of the immunotoxin bind are identified and characterize the immunotoxins. Methods of killing human ovarian cancer cells, retarding the growth of human ovarian cancer tumors in mammals or extending the survival of mammals carrying human ovarian cancer tumors are claimed.
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