发明公开
- 专利标题： Peptides having ANF activity
- 专利标题（中）： 肽ANF-Wirkung。
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申请号： EP87300545.8申请日： 1987-01-22
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公开(公告)号： EP0232078A2公开(公告)日： 1987-08-12
- 发明人: Nutt, Ruth F. , Verber, Daniel F. , Brady, Stephen F. , Lyle, Terry A.
- 申请人： Merck & Co., Inc.
- 申请人地址： 126, East Lincoln Avenue P.O. Box 2000 Rahway New Jersey 07065-0900 US
- 专利权人： Merck & Co., Inc.
- 当前专利权人： Merck & Co., Inc.
- 当前专利权人地址： 126, East Lincoln Avenue P.O. Box 2000 Rahway New Jersey 07065-0900 US
- 代理机构： Cole, William Gwyn
- 优先权： US824406 19860131
- 主分类号： C07K7/08
- IPC分类号： C07K7/08 ; C07K7/10 ; A61K37/24
摘要：
Novel peptides having potent natriuretic activity are disclosed with the following amino acid sequence: wherein X is L-Ile, D-Ile, D-Ilo-Ile, L-Met or D-Met, Y is Gly, L-Ala or D-Ala, A is H, Ser, Ser-Ser, Arg-Ser-Ser, Arg-Arg-Ser-Ser, Leu-Arg-Arg-Ser-Ser or Ser-Leu-Arg-Arg-Ser-Ser and B is OH, Asn, Asn-Ser, Asn-Ser-Phe, Asn-Ser-Phe-Arg, or Asn-Ser-Phe-Arg-Tyr, and all optically active amino acid residues may be D or L provided at least one amino acid has D-configuration, and the amides, lower alkyl esters and the physiologically acceptable metal salts and acid addition salts thereof.
公开/授权文献
- EP0232078A3 Peptides having ANF activity 公开/授权日：1990-03-14
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