发明公开
- 专利标题： Mixed phosphoric diesters, preparation thereof, and use thereof as antiinflammatory agents
- 专利标题（中）： 混合磷酸钙，其制备方法及其作为抗炎剂的用途
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申请号： EP87301842.8申请日： 1987-03-03
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公开(公告)号： EP0236120A3公开(公告)日： 1989-10-11
- 发明人: Yamamoto, Itaru , Ogata, Kazumi
- 申请人： Senju Seiyaku Kabushiki Kaisha also known as Senju Pharmaceutical Co. Ltd.
- 申请人地址： 5-8, Hirano-machi 2-chome Chuo-ku Osaka 541 JP
- 专利权人： Senju Seiyaku Kabushiki Kaisha also known as Senju Pharmaceutical Co. Ltd.
- 当前专利权人： Senju Seiyaku Kabushiki Kaisha also known as Senju Pharmaceutical Co. Ltd.
- 当前专利权人地址： 5-8, Hirano-machi 2-chome Chuo-ku Osaka 541 JP
- 代理机构： Burford, Anthony Frederick
- 优先权： JP46878/86 19860304
- 主分类号： C07F9/12
- IPC分类号： C07F9/12 ; A61K31/665
摘要：
Phosphoric diesters of general formula:
[wherein R₁ and R₂ are the same or different and each means a methyl group or a hydrogen atom, provided that at least one of R₁ and R₂ is a hydrogen atom, or a salt thereof] can be produced by reacting β, γ or δ-tocopherol with a halophosphorylating agent such as phosphorus oxychloride, reacting the resultant product with ascorbic acid whereof hydroxyl groups at 5- and 6-positions are protected, and then removing protected groups from the hydroxy groups. The phosphoric diesters are novel compounds having antiinflammatory activity.
[wherein R₁ and R₂ are the same or different and each means a methyl group or a hydrogen atom, provided that at least one of R₁ and R₂ is a hydrogen atom, or a salt thereof] can be produced by reacting β, γ or δ-tocopherol with a halophosphorylating agent such as phosphorus oxychloride, reacting the resultant product with ascorbic acid whereof hydroxyl groups at 5- and 6-positions are protected, and then removing protected groups from the hydroxy groups. The phosphoric diesters are novel compounds having antiinflammatory activity.
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