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1.发明授权Mixed phosphoric diesters, preparation thereof, and use thereof as antiinflammatory agents 失效混合磷酸钙，其制备方法及其作为抗炎剂的用途
公开(公告)号：EP0236120B1
公开(公告)日：1992-08-19
申请号：EP87301842.8
申请日：1987-03-03
发明人： Yamamoto, Itaru , Ogata, Kazumi
IPC分类号： C07F9/12 , A61K31/665
CPC分类号： A61K31/665 , C07F9/65586 , Y02P20/55
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2.发明公开Phosporic acid diesters, their salts, compositions containing them and a process for producing said diesters and salts 失效磷酸，它们的盐，含有它们的组合物和方法用于制备这种二酯和盐。
公开(公告)号：EP0127471A2
公开(公告)日：1984-12-05
申请号：EP84303566.8
申请日：1984-05-25
发明人： Ogata, Kazumi
IPC分类号： C07F9/12 , A61K31/665 , A61K7/48
CPC分类号： A61Q19/00 , A61K8/678 , A61Q19/02 , C07F9/65586 , Y02P20/55
摘要： Phosphoric acid diesters of the formula:
and salts thereof are produced by reacting a-tocopherol with a halogenophosphorylating agent, reacting the resultant product with ascorbic acid having protecting hydroxy groups in the 5- and 6-positions, and removing the protected groups. The compounds can be employed as prophylactic and therapeutic agents for cataracts and climacteric hazards and also as an ingredient for cosmetics having skin-beautifying action.摘要翻译： 式的磷酸二酯：...
...和其盐是通过使α生育酚与halogenophosphorylating剂起反应用抗坏血酸将所得产物具有在5-和6-位的羟基保护基，和除去所产生的 受保护的群体。 的化合物可以用作用于白内障和更年期危险预防和治疗剂和以配料具有美肤作用的化妆品。 -
公开(公告)号：EP0091761B1
公开(公告)日：1987-11-19
申请号：EP83301847.6
申请日：1983-03-31
申请人： Takeda Chemical Industries, Ltd. , Senju Seiyaku Kabushiki Kaisha also known as Senju Pharmaceutical Co. Ltd.
IPC分类号： C07D277/34
CPC分类号： C07D277/34 , Y10S514/866
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4.发明公开Mixed phosphoric diesters, preparation thereof, and use thereof as antiinflammatory agents 失效GemischtePhosphorsäurediester，ihre Herstellung und Verwendung alsentzündungshemmendeMittel。
公开(公告)号：EP0236120A2
公开(公告)日：1987-09-09
申请号：EP87301842.8
申请日：1987-03-03
发明人： Yamamoto, Itaru , Ogata, Kazumi
IPC分类号： C07F9/12 , A61K31/665
CPC分类号： A61K31/665 , C07F9/65586 , Y02P20/55
摘要： Phosphoric diesters of general formula:
[wherein R₁ and R₂ are the same or different and each means a methyl group or a hydrogen atom, provided that at least one of R₁ and R₂ is a hydrogen atom, or a salt thereof] can be produced by reacting β, γ or δ-tocopherol with a halophosphorylating agent such as phosphorus oxychloride, reacting the resultant product with ascorbic acid whereof hydroxyl groups at 5- and 6-positions are protected, and then removing protected groups from the hydroxy groups. The phosphoric diesters are novel compounds having antiinflammatory activity.摘要翻译： 磷酸二酯：...
... [其中R1和R2相同或不同，各自表示甲基或氢原子，条件是R 1和R 2中的至少一个为氢原子，或其盐 ]可以通过使β，γ或δ-生育酚与卤代磷酰化剂如磷酰氯反应，使所得产物与抗坏血酸反应，其中5-和6-位的羟基被保护，然后从羟基上除去保护基团 组。 磷酸二酯是具有抗炎活性的新型化合物。 -
5.发明授权Phosporic acid diesters, their salts, compositions containing them and a process for producing said diesters and salts 失效磷酸钙，它们的油，含有它们的组合物和生产上述柴油和油的方法
公开(公告)号：EP0127471B1
公开(公告)日：1987-09-09
申请号：EP84303566.8
申请日：1984-05-25
发明人： Ogata, Kazumi
IPC分类号： C07F9/12 , A61K31/665 , A61K7/48
CPC分类号： A61Q19/00 , A61K8/678 , A61Q19/02 , C07F9/65586 , Y02P20/55
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6.发明公开Mixed phosphoric diesters, preparation thereof, and use thereof as antiinflammatory agents 失效混合磷酸钙，其制备方法及其作为抗炎剂的用途
公开(公告)号：EP0236120A3
公开(公告)日：1989-10-11
申请号：EP87301842.8
申请日：1987-03-03
发明人： Yamamoto, Itaru , Ogata, Kazumi
IPC分类号： C07F9/12 , A61K31/665
CPC分类号： A61K31/665 , C07F9/65586 , Y02P20/55
摘要： Phosphoric diesters of general formula:
[wherein R₁ and R₂ are the same or different and each means a methyl group or a hydrogen atom, provided that at least one of R₁ and R₂ is a hydrogen atom, or a salt thereof] can be produced by reacting β, γ or δ-tocopherol with a halophosphorylating agent such as phosphorus oxychloride, reacting the resultant product with ascorbic acid whereof hydroxyl groups at 5- and 6-positions are protected, and then removing protected groups from the hydroxy groups. The phosphoric diesters are novel compounds having antiinflammatory activity.摘要翻译： 磷酸二酯：...
... [其中R1和R2相同或不同，各自表示甲基或氢原子，条件是R 1和R 2中的至少一个为氢原子，或其盐 ]可以通过使β，γ或δ-生育酚与卤代磷酰化剂如磷酰氯反应，使所得产物与抗坏血酸反应，其中5-和6-位的羟基被保护，然后从羟基上除去保护基团 组。 磷酸二酯是具有抗炎活性的新型化合物。 -
7.发明公开Phosporic acid diesters, their salts, compositions containing them and a process for producing said diesters and salts 失效磷酸二水合物及其盐，含有它们的组合物和用于生产柴油和盐的方法
公开(公告)号：EP0127471A3
公开(公告)日：1985-08-14
申请号：EP84303566
申请日：1984-05-25
发明人： Ogata, Kazumi
IPC分类号： C07F09/12 , A61K31/665 , A61K07/48
CPC分类号： A61Q19/00 , A61K8/678 , A61Q19/02 , C07F9/65586 , Y02P20/55
摘要： Phosphoric acid diesters of the formula:
and salts thereof are produced by reacting a-tocopherol with a halogenophosphorylating agent, reacting the resultant product with ascorbic acid having protecting hydroxy groups in the 5- and 6-positions, and removing the protected groups. The compounds can be employed as prophylactic and therapeutic agents for cataracts and climacteric hazards and also as an ingredient for cosmetics having skin-beautifying action.-
公开(公告)号：EP0091761A3
公开(公告)日：1984-12-27
申请号：EP83301847
申请日：1983-03-31
申请人： Takeda Chemical Industries, Ltd. , Senju Seiyaku Kabushiki Kaisha also known as Senju Pharmaceutical Co. Ltd.
IPC分类号： C07D277/34 , C07D277/54
CPC分类号： C07D277/34 , Y10S514/866
摘要： A new thiazolidine derivative of the formula:
where n stands for an integer of 3 to 6 and salts thereof show strong aldose reductase inhibition and are useful for prophylaxis or therapy of diabetic cataract, diabetic neuropathy in mammals.-
公开(公告)号：EP0091761A2
公开(公告)日：1983-10-19
申请号：EP83301847.6
申请日：1983-03-31
申请人： Takeda Chemical Industries, Ltd. , Senju Seiyaku Kabushiki Kaisha also known as Senju Pharmaceutical Co. Ltd.
IPC分类号： C07D277/34
CPC分类号： C07D277/34 , Y10S514/866
摘要： A new thiazolidine derivative of the formula:
where n stands for an integer of 3 to 6 and salts thereof show strong aldose reductase inhibition and are useful for prophylaxis or therapy of diabetic cataract, diabetic neuropathy in mammals.-
10.发明公开Thiazolidine derivatives and their production and medicinal compositions containing them 失效噻唑烷衍生物以及它们的制备方法和它们的药物组合物。
公开(公告)号：EP0033617A2
公开(公告)日：1981-08-12
申请号：EP81300308.4
申请日：1981-01-23
申请人： Takeda Chemical Industries, Ltd. , Senju Seiyaku Kabushiki Kaisha also known as Senju Pharmaceutical Co. Ltd.
IPC分类号： C07D277/34 , C07D409/04 , A61K31/425 , C07D277/54 , C07D277/40
CPC分类号： C07D417/04 , C07C255/00 , C07D277/34 , C07D277/40 , C07D277/54
摘要： A thiazolidine derivatives of the formula:
wherein R is a phenyl group having 2 nuclear substituent groups selected from the class consisting of a lower alkyl having 1 to 6 carbon atoms, a lower alkoxy having 1 to 7 carbon atoms, hydroxyl and a carboxylic acyloxy having 1 to4 carbon atoms or a phenyl group having a methylenedioxy group in adjacent positions on its ring; R' is H or an alkyl having 1 to 6 carbon atoms, or a physiologically acceptable salt thereof is a novel compound and is having the activity to control certain chronic symptoms due to diabetes, such as diabetic cataract, diabetic neuropathy and diabetic retinosis.
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