发明公开
- 专利标题： 4-Halogeno-2-Oxyimino-3-Oxobutyric acids
- 专利标题（中）： 4-卤代-2-氧代亚氨基-3-氧代丁酸
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申请号： EP87107226.0申请日： 1987-05-19
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公开(公告)号： EP0246603A3公开(公告)日： 1989-09-27
- 发明人: Naito, Kenzo , Ishibashi, Yukio
- 申请人： Takeda Chemical Industries, Ltd.
- 申请人地址： 1-1, Doshomachi 4-chome Chuo-ku, Osaka JP
- 专利权人： Takeda Chemical Industries, Ltd.
- 当前专利权人： Takeda Chemical Industries, Ltd.
- 当前专利权人地址： 1-1, Doshomachi 4-chome Chuo-ku, Osaka JP
- 代理机构： von Kreisler, Alek, Dipl.-Chem.
- 优先权： JP116673/86 19860521
- 主分类号： C07C249/00
- IPC分类号： C07C249/00 ; C07C251/00 ; C07F7/18
摘要：
A method of producing a 4-halo-2-(substituted or unsubstituted)hydroxyimino-3-oxobutyric acid ester or amide, which is a synthetic intermediate of value for the production of cephalosporins containing an aminothiazole group, characterized by reacting a 2-(substituted or unsubstituted)hydroxyimino-3-oxobutyric acid or an ester or amide thereof with a silylating agent and reacting the resulting novel 2-(substituted)hydroxyimino-3-silyloxy-3-butenoic acid ester or amide with a halogenating agent.
公开/授权文献
- EP0246603B1 4-Halogeno-2-Oxyimino-3-Oxobutyric acids 公开/授权日：1992-12-30
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