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    PEPTIDE COMPOUND PRODUCTION METHOD
    1.
    发明公开
    PEPTIDE COMPOUND PRODUCTION METHOD 审中-公开

    公开(公告)号：EP4446332A1

    公开(公告)日：2024-10-16

    申请号：EP23740309.2

    申请日：2023-01-12

    申请人： Chubu University Educational Foundation

    发明人： YAMAMOTO, Hisashi ,  HATTORI, Tomohiro

    IPC分类号： C07K1/06 ,  C07F7/18

    摘要： Provided is a method that prevents decreases in solubility in an organic solvent when elongating a peptide chain by a peptide coupling reaction and improves the reactivity of a peptide chain and the operability in a purification process. The method makes it possible to obtain a polypeptide compound represented by formula (P1) by performing amide formation reaction of the carboxyl group on the right side of the amino acid or the peptide compound in formula (R1) with the amino group on the left side of the amino acid or the peptide ester compound in formula (R2) in which the terminal carboxyl group is protected by a silicon-containing hydrophobic substituent TAG(Si).

    METHOD FOR PRODUCING ALKOXYSILYL ALKYLAMINOPROPYL-MODIFIED POLYSILOXANE COMPOUND
    5.
    发明公开
    METHOD FOR PRODUCING ALKOXYSILYL ALKYLAMINOPROPYL-MODIFIED POLYSILOXANE COMPOUND 审中-实审

    公开(公告)号：EP4410796A1

    公开(公告)日：2024-08-07

    申请号：EP22875757.1

    申请日：2022-09-08

    申请人： SHIN-ETSU CHEMICAL CO., LTD.

    发明人： KAWAKAMI Masato

    IPC分类号： C07F7/18 ,  C08G77/388 ,  C08G77/54

    CPC分类号： C08G77/388 ,  C07F7/18 ,  C08G77/54

    摘要： According to the present invention, a method for producing a compound represented by general formula (3) by having a compound represented by general formula (1) and a compound represented by genera formula (2) react with each other reaches a sufficient reaction rate at a low temperature in a short time, and provides an alkoxysilyl alkylaminoalkyl-modified polysiloxane compound which has a low polymer content and good storage stability, while being suppressed in coloration.

    (In general formula (1), R1 represents a monovalent hydrocarbon group; X represents a hydrogen atom or R13Si (wherein R1 is as described above); and p represents an integer of 1 to 1,000.)

    (In general formula (2), each of R2 and R3 represents a monovalent hydrocarbon group; R4 represents a divalent hydrocarbon group which may contain a sulfur atom or the like; q represents 0 or 1; and r represents 0, 1 or 2.)

    (In general formula (3), R1 to R4, p, q and r are as described above; and Y represents a substituent represented by general formula (4)

    (wherein R2 to R4, q and r are as described above) or R13Si (wherein R1 is as described above).)