发明公开
EP0251827A2 New cyclic ether derivatives, their preparation and their use
失效
Zyklische Ether-Derivate，Verfahren zu deren Herstellung und deren Anwendung。
- 专利标题： New cyclic ether derivatives, their preparation and their use
- 专利标题（中）： Zyklische Ether-Derivate，Verfahren zu deren Herstellung und deren Anwendung。
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申请号： EP87305972.9申请日： 1987-07-06
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公开(公告)号： EP0251827A2公开(公告)日： 1988-01-07
- 发明人: Nakamura, Norio Sankyo Company Limited , Miyazaki, Hideki Sankyo Company Limited , Koike, Hiroyuki Sankyo Company Limited , Oshima, Takeshi Sankyo Company Limited
- 申请人： Sankyo Company Limited
- 申请人地址： 5-1 Nihonbashi Honcho 3-chome Chuo-ku Tokyo JP
- 专利权人： Sankyo Company Limited
- 当前专利权人： Sankyo Company Limited
- 当前专利权人地址： 5-1 Nihonbashi Honcho 3-chome Chuo-ku Tokyo JP
- 代理机构： Gibson, Christian John Robert
- 优先权： JP157319/86 19860704; JP15484/86 19870126
- 主分类号： C07D417/12
- IPC分类号： C07D417/12 ; A61K31/335 ; C07D405/12 ; C07D413/12 ; C07D413/04 ; C07D307/20 ; C07D307/18 ; C07D313/04 ; C07D309/12 ; A61K31/34 ; A61K31/35
摘要：
Compounds of formula (I):
[wherein: I is 2 - 4; A and B are oxygen or sulphur; one of R 1 and R 2 represents a long chain alkyl, alkylcarbamoyl or aliphatic acyl group and the other of R 1 and R 2 represents a group of formula (III) :
in which E represents a single bond, a bivalent heterocyclic group or a group of formula -CO-, -COO- or -CONR 6 -, where R 6 is hydrogen or an imino-protecting group; m is 0 - 3; n is 0 -10; q is 0 or 1; R 4 is optionally protected hydroxy, mercapto or carboxy; and Q is an amino or nitrogen-containing heterocyclic group] are PAF antagonists which may be used to treat asthma, hypotension, inflammation and shock. They may be prepared by introducing the appropriate group R 1 and/or R 2 into a compound In which one or both of these groups is replaced by an active group.
[wherein: I is 2 - 4; A and B are oxygen or sulphur; one of R 1 and R 2 represents a long chain alkyl, alkylcarbamoyl or aliphatic acyl group and the other of R 1 and R 2 represents a group of formula (III) :
in which E represents a single bond, a bivalent heterocyclic group or a group of formula -CO-, -COO- or -CONR 6 -, where R 6 is hydrogen or an imino-protecting group; m is 0 - 3; n is 0 -10; q is 0 or 1; R 4 is optionally protected hydroxy, mercapto or carboxy; and Q is an amino or nitrogen-containing heterocyclic group] are PAF antagonists which may be used to treat asthma, hypotension, inflammation and shock. They may be prepared by introducing the appropriate group R 1 and/or R 2 into a compound In which one or both of these groups is replaced by an active group.
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