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1.发明公开New cyclic ether derivatives, their preparation and their use 失效Zyklische Ether-Derivate，Verfahren zu deren Herstellung und deren Anwendung。
公开(公告)号：EP0251827A2
公开(公告)日：1988-01-07
申请号：EP87305972.9
申请日：1987-07-06
发明人： Nakamura, Norio Sankyo Company Limited , Miyazaki, Hideki Sankyo Company Limited , Koike, Hiroyuki Sankyo Company Limited , Oshima, Takeshi Sankyo Company Limited
IPC分类号： C07D417/12 , A61K31/335 , C07D405/12 , C07D413/12 , C07D413/04 , C07D307/20 , C07D307/18 , C07D313/04 , C07D309/12 , A61K31/34 , A61K31/35
CPC分类号： C07D405/12 , C07D307/20 , C07D309/10 , C07D313/04 , C07D417/12 , C07D417/14 , Y02P20/55
摘要： Compounds of formula (I):
[wherein: I is 2 - 4; A and B are oxygen or sulphur; one of R 1 and R 2 represents a long chain alkyl, alkylcarbamoyl or aliphatic acyl group and the other of R 1 and R 2 represents a group of formula (III) :
in which E represents a single bond, a bivalent heterocyclic group or a group of formula -CO-, -COO- or -CONR 6 -, where R 6 is hydrogen or an imino-protecting group; m is 0 - 3; n is 0 -10; q is 0 or 1; R 4 is optionally protected hydroxy, mercapto or carboxy; and Q is an amino or nitrogen-containing heterocyclic group] are PAF antagonists which may be used to treat asthma, hypotension, inflammation and shock. They may be prepared by introducing the appropriate group R 1 and/or R 2 into a compound In which one or both of these groups is replaced by an active group.摘要翻译： 式（I）的化合物：
[其中：l是2-4; A和B是氧或硫; R 1和R 2之一表示长链烷基，烷基氨基甲酰基或脂族酰基，R 1和R 2中的另一个表示式（III）的基团：其中E 表示单键，二价杂环基或式-CO-，-COO-或-CONR 6 - 的基团，其中R 6是氢或亚氨基保护基; m为0-3; n为0〜10; q为0或l; R 4任选被保护为羟基，巯基或羧基; 和Q是氨基或含氮杂环基]是可用于治疗哮喘，低血压，炎症和休克的PAF拮抗剂。 它们可以通过将适当的基团R 1和/或R 2引入其中这些基团中的一个或两个被活性基团替代的化合物中来制备。 -
公开(公告)号：EP0251827A3
公开(公告)日：1989-08-23
申请号：EP87305972.9
申请日：1987-07-06
发明人： Nakamura, Norio Sankyo Company Limited , Miyazaki, Hideki Sankyo Company Limited , Koike, Hiroyuki Sankyo Company Limited , Oshima, Takeshi Sankyo Company Limited
IPC分类号： C07D417/12 , A61K31/335 , C07D405/12 , C07D413/12 , C07D413/04 , C07D307/20 , C07D307/18 , C07D313/04 , C07D309/12 , A61K31/34 , A61K31/35
CPC分类号： C07D405/12 , C07D307/20 , C07D309/10 , C07D313/04 , C07D417/12 , C07D417/14 , Y02P20/55
摘要： Compounds of formula (I):
[wherein: I is 2 - 4; A and B are oxygen or sulphur; one of R 1 and R 2 represents a long chain alkyl, alkylcarbamoyl or aliphatic acyl group and the other of R 1 and R 2 represents a group of formula (III) :
in which E represents a single bond, a bivalent heterocyclic group or a group of formula -CO-, -COO- or -CONR 6 -, where R 6 is hydrogen or an imino-protecting group; m is 0 - 3; n is 0 -10; q is 0 or 1; R 4 is optionally protected hydroxy, mercapto or carboxy; and Q is an amino or nitrogen-containing heterocyclic group] are PAF antagonists which may be used to treat asthma, hypotension, inflammation and shock. They may be prepared by introducing the appropriate group R 1 and/or R 2 into a compound In which one or both of these groups is replaced by an active group.-
公开(公告)号：EP0251827B1
公开(公告)日：1993-09-15
申请号：EP87305972.9
申请日：1987-07-06
发明人： Nakamura, Norio Sankyo Company Limited , Miyazaki, Hideki Sankyo Company Limited , Koike, Hiroyuki Sankyo Company Limited , Oshima, Takeshi Sankyo Company Limited
IPC分类号： C07D417/12 , A61K31/335 , C07D405/12 , C07D413/12 , C07D413/04 , C07D307/20 , C07D307/18 , C07D313/04 , C07D309/12 , A61K31/34 , A61K31/35
CPC分类号： C07D405/12 , C07D307/20 , C07D309/10 , C07D313/04 , C07D417/12 , C07D417/14 , Y02P20/55
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