发明公开
EP0255249A2 Monoclonal antibodies to Fc receptors for immunoglobulin G on human mononuclear phagocytes; bifunctional antibodies; target specific effector cells; targeted macrophages; and immunoassays
失效
抗人单核吞噬细胞免疫球蛋白G的Fc受体的单克隆抗体; 双功能抗体; 靶向特异性效应细胞; 有针对性的巨噬细胞和免疫测定。
- 专利标题： Monoclonal antibodies to Fc receptors for immunoglobulin G on human mononuclear phagocytes; bifunctional antibodies; target specific effector cells; targeted macrophages; and immunoassays
- 专利标题（中）： 抗人单核吞噬细胞免疫球蛋白G的Fc受体的单克隆抗体; 双功能抗体; 靶向特异性效应细胞; 有针对性的巨噬细胞和免疫测定。
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申请号： EP87305998.4申请日： 1987-07-07
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公开(公告)号： EP0255249A2公开(公告)日： 1988-02-03
- 发明人: Fanger, Michael W. , Guyre, Paul M. , Anderson, Clark L.
- 申请人： MEDAREX, INC.
- 申请人地址： P.O. Box 953 1545 Route 22 East Annandale New Jersey 08801-0953 US
- 专利权人： MEDAREX, INC.
- 当前专利权人： MEDAREX, INC.
- 当前专利权人地址： P.O. Box 953 1545 Route 22 East Annandale New Jersey 08801-0953 US
- 代理机构： Harvey, David Gareth
- 优先权： US882181 19860707; US69412 19870701
- 主分类号： C12P21/08
- IPC分类号： C12P21/08 ; A61K39/395 ; G01N33/577 ; G01N33/68
摘要：
A human Fc receptor-specific monoclonal antibody is disclosed together with its mode of preparation. Binding of the antibody to Fc receptor is not blocked by human immunoglobulin G. The antibody binds to the high affinity Fc receptor for IgG on human monocytes at a receptor binding site distinct from the ligand binding site for Fc.
A bifunctional antibody or a heteroantibody has an antigen binding region derived from an anti-Fc receptor antibody and an antigen binding region specific for a target epitope or cell; such antibody may target a macrophage when it is bound to surface Fc receptors of the macrophage.
A target-specific effector cell expresses receptor for the Fg portion of IgG, has one antigen binding region derived from an anti-Fc receptor antibody and another specific for a target cell, and the aforesaid bifunctional or hetero-antibody is bound to the Fc receptor of the effector cell; such effector cell can be used in the therapy of cancers, allergies, infectious and autoimmune diseases, and in immunoassays.
A bifunctional antibody or a heteroantibody has an antigen binding region derived from an anti-Fc receptor antibody and an antigen binding region specific for a target epitope or cell; such antibody may target a macrophage when it is bound to surface Fc receptors of the macrophage.
A target-specific effector cell expresses receptor for the Fg portion of IgG, has one antigen binding region derived from an anti-Fc receptor antibody and another specific for a target cell, and the aforesaid bifunctional or hetero-antibody is bound to the Fc receptor of the effector cell; such effector cell can be used in the therapy of cancers, allergies, infectious and autoimmune diseases, and in immunoassays.
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