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    Monoclonal antibodies to Fc receptors for immunoglobulin G on human mono-nuclear phagocytes, bifunctional antibodies, target specific effector cells, targeted macrophages, and innunoassays
    1.
    发明公开
    Monoclonal antibodies to Fc receptors for immunoglobulin G on human mono-nuclear phagocytes, bifunctional antibodies, target specific effector cells, targeted macrophages, and innunoassays 失效
    抗人单核吞噬细胞免疫球蛋白G的Fc受体的单克隆抗体; 双功能抗体; 靶向特异性效应细胞; 有针对性的巨噬细胞和免疫测定。

    公开(公告)号：EP0629703A3

    公开(公告)日：1995-03-22

    申请号：EP94202572.7

    申请日：1987-07-07

    申请人： MEDAREX, INC.

    发明人： Fanger, Michael W. ,  Guyre, Paul M. ,  Anderson, Clark L.

    IPC分类号： C12P21/00 ,  A61K39/395 ,  G01N33/577 ,  G01N33/68

    CPC分类号： A61K35/15 ,  A61K38/00 ,  A61K2039/505 ,  C07K16/283 ,  C07K16/3023 ,  C07K16/468 ,  C07K2317/31 ,  C07K2317/55 ,  C07K2317/73 ,  C07K2317/732 ,  G01N33/56972 ,  Y10S530/806 ,  Y10S530/809

    摘要： A human Fc receptor-specific monoclonal antibody is disclosed together with its mode of preparation. Binding of the antibody to Fc receptor is not blocked by human immunoglobulin G. The antibody binds to the high affinity Fc receptor for IgG on human monocytes at a receptor binding site distinct from the ligand binding site for Fc. A bifunctional antibody or a heteroantibody has an antigen binding region derived from an anti-Fc receptor antibody and an antigen binding region specific for a target epitope or cell; such antibody may target a macrophage when it is bound to surface Fc receptors of the macrophage. A target-specific effector cell expresses receptor for the Fg portion of IgG, has one antigen binding region derived from an anti-Fc receptor antibody and another specific for a target cell, and the aforesaid bifunctional or hetero-antibody is bound to the Fc receptor of the effector cell; such effector cell can be used in the therapy of cancers, allergies, infectious and autoimmune diseases, and in immunoassays.

    摘要翻译： 人Fc受体特异性单克隆抗体是用圆盘其制备方式一起游离缺失。 不阻止抗体与Fc受体的结合由人免疫球蛋白G的抗体结合在受体结合位点由对Fc配体的结合位点不同的高亲和力Fc受体IgG的人单核细胞。 双功能抗体或杂抗体具有抗原结合从在抗Fc受体抗体和特异于靶表位或细胞的抗原结合区衍生的区域; 当它被结合到表面上的巨噬细胞的Fc受体抗体寻求可以靶向巨噬细胞。 对于IgG的纤维蛋白原部分A靶标特异性效应细胞快车受体，具有从在抗Fc受体抗体和另一种特异于靶细胞的一个抗原结合区域，和上述双官能或杂抗体结合于Fc受体 效应细胞的; 求的效应细胞可以在癌症，过敏症，感染和自身免疫性疾病的治疗中使用，并在免疫测定。

    Bispecific reagents for aids therapy
    4.
    发明公开
    Bispecific reagents for aids therapy 失效
    Bispezifische Reagenzienfürdie AIDS-Therapie

    公开(公告)号：EP0739904A1

    公开(公告)日：1996-10-30

    申请号：EP96201024.5

    申请日：1990-06-29

    申请人： MEDAREX, INC.

    发明人： Fanger, Michael W. ,  Guyre, Paul M. ,  Dinces, Nathan B.

    IPC分类号： C07K16/46 ,  C07K16/28 ,  C07K16/10 ,  C12N5/00 ,  A61K39/395 ,  A61K35/12

    CPC分类号： C07K14/005 ,  A61K38/00 ,  A61K47/68 ,  A61K47/6839 ,  A61K47/6849 ,  A61K47/6879 ,  C07K14/70514 ,  C07K16/1063 ,  C07K16/283 ,  C07K16/468 ,  C07K2319/00 ,  C12N2740/16122

    摘要： Bispecific molecules which react both with the high-affinity Fcγ receptor of human effector cells and with a virus or virus component are disclosed. Binding of the molecules to the Fc receptors found on effector cells is not blocked by human immunoglobulin G. The molecules are useful for targeting human effector cells (e.g. macrophages) against a viral target (e.g. HIV or BIV-infected cell). For this purpose, bispecific molecules can be constructed containing the binding region derived from an anti-Fcγ receptor antibody and the CD4 molecule or CD4 binding domain of the envelope glycoprotein gp120 of BIV. Alternatively, bispecific antibodies or heteroantibodies can be constructed containing the binding region derived from an anti-Fc receptor antibody and the binding region of HIV-specific antibody such as anti-gp120 antibody. Targeted effector cells can be used to kill virus by cell mediated antibody dependent cytolysis.

    摘要翻译： 公开了与人效应细胞的高亲和力Fcγ受体和病毒或病毒组分反应的双特异性分子。 分子与效应细胞上发现的Fc受体的结合不被人免疫球蛋白G阻断。该分子可用于靶向针对病毒靶（例如HIV或BIV感染细胞）的人效应细胞（例如巨噬细胞）。 为此，可以构建双特异性分子，其含有衍生自抗Fcγ受体抗体的结合区域和BIV的包膜糖蛋白gp120的CD4分子或CD4结合结构域。 或者，可以构建含有衍生自抗Fc受体抗体的结合区和HIV特异性抗体如抗-gp120抗体的结合区的双特异性抗体或异种抗体。 靶向效应细胞可用于通过细胞介导的抗体依赖性细胞溶解来杀死病毒。

    Monoclonal antibodies to Fc receptors for immunoglobulin G on human mononuclear phagocytes; bifunctional antibodies; target specific effector cells; targeted macrophages; and immunoassays
    6.
    发明公开
    Monoclonal antibodies to Fc receptors for immunoglobulin G on human mononuclear phagocytes; bifunctional antibodies; target specific effector cells; targeted macrophages; and immunoassays 失效
    抗人单核吞噬细胞免疫球蛋白G的Fc受体的单克隆抗体; 双功能抗体; 靶向特异性效应细胞; 有针对性的巨噬细胞和免疫测定。

    公开(公告)号：EP0255249A2

    公开(公告)日：1988-02-03

    申请号：EP87305998.4

    申请日：1987-07-07

    申请人： MEDAREX, INC.

    发明人： Fanger, Michael W. ,  Guyre, Paul M. ,  Anderson, Clark L.

    IPC分类号： C12P21/08 ,  A61K39/395 ,  G01N33/577 ,  G01N33/68

    CPC分类号： A61K35/15 ,  A61K38/00 ,  A61K2039/505 ,  C07K16/283 ,  C07K16/3023 ,  C07K16/468 ,  C07K2317/31 ,  C07K2317/55 ,  C07K2317/73 ,  C07K2317/732 ,  G01N33/56972 ,  Y10S530/806 ,  Y10S530/809

    摘要： A human Fc receptor-specific monoclonal antibody is disclosed together with its mode of preparation. Binding of the antibody to Fc receptor is not blocked by human immunoglobulin G. The antibody binds to the high affinity Fc receptor for IgG on human monocytes at a receptor binding site distinct from the ligand binding site for Fc.
    A bifunctional antibody or a heteroantibody has an antigen binding region derived from an anti-Fc receptor antibody and an antigen binding region specific for a target epitope or cell; such antibody may target a macrophage when it is bound to surface Fc receptors of the macrophage.
    A target-specific effector cell expresses receptor for the Fg portion of IgG, has one antigen binding region derived from an anti-Fc receptor antibody and another specific for a target cell, and the aforesaid bifunctional or hetero-antibody is bound to the Fc receptor of the effector cell; such effector cell can be used in the therapy of cancers, allergies, infectious and autoimmune diseases, and in immunoassays.

    摘要翻译： 人Fc受体特异性单克隆抗体是用圆盘其制备方式一起游离缺失。 不阻止抗体与Fc受体的结合由人免疫球蛋白G的抗体结合在受体结合位点由对Fc配体的结合位点不同的高亲和力Fc受体IgG的人单核细胞。 双功能抗体或杂抗体具有抗原结合从在抗Fc受体抗体和特异于靶表位或细胞的抗原结合区衍生的区域; 当它被结合到表面上的巨噬细胞的Fc受体抗体寻求可以靶向巨噬细胞。 对于IgG的纤维蛋白原部分A靶标特异性效应细胞快车受体，具有从在抗Fc受体抗体和另一种特异于靶细胞的一个抗原结合区域，和上述双官能或杂抗体结合于Fc受体 效应细胞的; 求的效应细胞可以在癌症，过敏症，感染和自身免疫性疾病的治疗中使用，并在免疫测定。