发明公开
- 专利标题： High level expression in yeast
- 专利标题（中）： Hohe蛋白合成酶在Hefe。
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申请号： EP88104649.4申请日： 1988-03-23
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公开(公告)号： EP0284044A1公开(公告)日： 1988-09-28
- 发明人: Irani, Meher H. , Kilgore, Tammy L.
- 申请人： ZYMOGENETICS, INC.
- 申请人地址： 4225 Roosevelt Way N.E. Seattle, WA 98108 US
- 专利权人： ZYMOGENETICS, INC.
- 当前专利权人： ZYMOGENETICS, INC.
- 当前专利权人地址： 4225 Roosevelt Way N.E. Seattle, WA 98108 US
- 代理机构： Brown, John David
- 优先权： US29867 19870323
- 主分类号： C12N15/67
- IPC分类号： C12N15/67 ; C12N15/81 ; C12N9/10
摘要：
Methods for the enhanced production of proteins, such as alpha-1-antitrypsin, in yeast host cells are disclosed. The methods generally include introducing a suitable expression vector into a yeast host cell having a genetic defect. The expression vector is capable of directing the expression of heterologous genes or cDNA in yeast and contains an ADH2 promoter, a heterologous gene or cDNA, and a defective selectable marker, the defective selectable marker complementing the genetic defect in the yeast host cell.
公开/授权文献
- EP0284044B1 High level expression in yeast 公开/授权日：1994-03-23
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