公开(公告)号：EP3732294B1

公开(公告)日：2025-02-26

申请号：EP18897769.8

申请日：2018-12-26

Inventor： MAJEED, Muhammed ,  NAGABHUSHANAM, Kalyanam ,  MUNDKUR, Lakshmi

IPC: A61K31/122 ,  A61P3/10 ,  A61K36/71 ,  A61K47/12 ,  A61K47/22 ,  C12N15/81 ,  C12N9/42 ,  C12P19/02 ,  B01D11/02

公开(公告)号：EP4491736A1

公开(公告)日：2025-01-15

申请号：EP22933753.0

申请日：2022-07-27

Applicant: CJ CheilJedang Corporation

Inventor： PARK, Hye Min ,  LEE, Peter ,  LEE, Dong Pil ,  KIM, Jae Eung

IPC: C12P23/00 ,  C12N15/81 ,  C12N1/16 ,  C12N1/38 ,  C12R1/645

Abstract: Provided are a method of producing retinol, the method comprising the step of culturing a microorganism of the genus Yarrowia in a medium containing an antioxidant; a method of increasing retinol production; a method of producing retinoids; a medium composition for a microorganism of the genus Yarrowia for producing retinol, the composition comprising an antioxidant; a composition for producing retinol, the composition comprising the microorganism or a culture thereof and an antioxidant.

公开(公告)号：EP4473099A1

公开(公告)日：2024-12-11

申请号：EP23703160.4

申请日：2023-02-01

Applicant: DSM IP Assets B.V.

Inventor： HOUSTON, Peter Louis ,  MAYORGA, Maria Elena ,  VYAS, Valmik Kanubhai ,  YORGEY, Peter Scott

IPC: C12N9/10 ,  C07C403/24 ,  C07K14/39 ,  C12N15/81 ,  C12P7/6463 ,  C12P7/6472

公开(公告)号：EP4423265A1

公开(公告)日：2024-09-04

申请号：EP22887988.8

申请日：2022-10-24

Applicant: Inscripta, Inc.

Inventor： HORWITZ, Andrew ,  APEL, Amanda Reider ,  TARASOW, Theodore M. ,  MIRSIAGHI, Mona ,  GRAVES, Christopher ,  BARBIERI, Charles

IPC: C12N15/10 ,  C12Q1/04 ,  C12N15/70 ,  C12N15/81

CPC classification number: C12Q1/04 ,  C40B30/06 ,  C12N15/1065 ,  C12N2310/2020170501

公开(公告)号：EP4296364A3

公开(公告)日：2024-08-21

申请号：EP23208030.9

申请日：2014-11-25

Applicant: Genomatica, Inc.

Inventor： Osterhout, Robin E. ,  Burgard, Anthony P. ,  Pharkya, Priti ,  Andrae, Stefan

IPC: C12N1/19 ,  C12N1/15 ,  C12N1/13 ,  C12N1/11 ,  C12N15/70 ,  C12N15/81 ,  C12P7/42 ,  C12P5/02 ,  C12P13/00 ,  C12P17/10 ,  C12N1/14 ,  C12N1/20 ,  C12P7/02 ,  C12P7/40 ,  C12P7/04 ,  C12P7/44 ,  C12P7/18

CPC classification number: C12N1/14 ,  C12N1/20 ,  C12P7/02 ,  C12P7/18 ,  C12P7/40 ,  C12P7/42 ,  Y02E50/30

Abstract: The invention provides non-naturally occurring microbial organisms containing enzymatic pathways and/or metabolic modifications for enhancing carbon flux through acetyl-CoA. In some embodiments, the microbial organisms having such pathways also include pathways for generating reducing equivalents, formaldehyde fixation and/or formate assimilation. The enhanced carbon flux through acetyl-CoA, in combination with pathways for generating reducing equivalents, formaldehyde fixation and/or formate assimilation can, in some embodiments, be used for production of a bioderived compound. Accordingly, in some embodiments, the microbial organisms of the invention can include a pathway capable of producing a bioderived compound of the invention. The invention still further provides a method for producing a bioderived compound of the invention.

公开(公告)号：EP4400519A1

公开(公告)日：2024-07-17

申请号：EP22909227.5

申请日：2022-06-30

Applicant: Shanghai Nk Cell Tech Co., Ltd.

Inventor： XIAO, Weihua ,  TIAN, Zhigang ,  LI, Yangyang ,  XIE, Siqi ,  CHEN, Minhua

IPC: C07K19/00 ,  C12N15/62 ,  C12N15/81 ,  C12N5/0783 ,  C12N1/19 ,  A61K38/17 ,  A61K39/395 ,  A61P31/04 ,  A61P35/00 ,  A61P35/02 ,  A61P31/14 ,  A61P31/16 ,  A61P31/20 ,  C12R1/84

CPC classification number: A61K38/17 ,  A61K39/395 ,  A61P31/04 ,  A61P31/14 ,  A61P31/16 ,  A61P35/00 ,  A61P35/02 ,  A61P31/20 ,  C07K19/00 ,  C12N5/06 ,  C12N15/62 ,  C12N15/81 ,  C12R2001/8420210501

Abstract: The present disclosure relates to the field of biomedicine, and specifically relates to a bispecific NK cell agonist, a preparation method, and a use. The present disclosure provides a fused protein. The fused protein uses a CD16A receptor and a 4-1BB receptor as targets to obtain a new bispecific NK cell agonist medicament, i.e., scfv-CD16A-Trimer-4-1BBL; the medicament has the activity of activating and amplifying an NK cell in vitro, enhancing the antivirus and antitumor capabilities of the NK cell, and has the potential effects of promoting NK cell proliferation and enhancing a T cell function, and has the application potential of culturing and amplifying the NK cells in vitro; and the amplified NK cells have good cytotoxicity.

公开(公告)号：EP3668321B1

公开(公告)日：2024-05-29

申请号：EP18755792.1

申请日：2018-08-14

IPC: A21D8/04 ,  A21D10/00 ,  A21D13/062 ,  C12N15/81 ,  A23L33/20

CPC classification number: A21D8/042 ,  A21D8/047 ,  A21D10/005 ,  A21D13/062 ,  A23L33/20

公开(公告)号：EP4370688A1

公开(公告)日：2024-05-22

申请号：EP22744732.3

申请日：2022-07-07

Applicant: DANISCO US INC

Inventor： ROSSELL-ARAGORT, Sergio Luis ,  JANSEN, Mickel Leonardus August ,  VUGT- VAN LUTZ, Ingrid Maria ,  SCHMITZ, Jozef Petrus Johannes ,  VAN RIJ, Evert Tjeerd ,  DE JONG, René Marcel

IPC: C12N15/81

CPC classification number: C12N15/81 ,  C12N9/1205 ,  C12N9/88 ,  Y02E50/10

公开(公告)号：EP4314272A1

公开(公告)日：2024-02-07

申请号：EP22782347.3

申请日：2022-04-01

Applicant: Ginkgo Bioworks, Inc.

Inventor： BEAUDOIN, Guillaume ,  EXNER, Alexandra ,  KAMINENI, Annapurna ,  MCMAHON, Matthew ,  TRUEHEART, Joshua

IPC: C12N9/90 ,  C12N15/52 ,  C12N15/81 ,  C12N9/10 ,  C12P19/18 ,  C12P19/56 ,  C12P33/00 ,  C12P5/00

公开(公告)号：EP3433354B1

公开(公告)日：2023-12-27

申请号：EP17771095.1

申请日：2017-03-22

Inventor： HUTCHISON, Clyde, A. III ,  CHUANG, Ray-yuan ,  NOSKOV, Vladimir, N. ,  KARAS, Bogumil, J. ,  WISE, Kim, S. ,  SMITH, Hamilton, O. ,  GLASS, John, I. ,  MERRYMAN, Chuck ,  GIBSON, Daniel, G. ,  VENTER, J., Craig ,  KANNAN, Krishna ,  DING, Lin

IPC: C12N15/10 ,  C12N15/74 ,  C12N15/81 ,  G16B30/20