发明公开
- 专利标题： Omega-quaternary ammonium alkyl esters and thioesters of acidic nonsteroidal antiinflammatory drugs
- 专利标题（中）： 欧米茄氨基酸酯和酸性非甾体抗炎药的硫酸盐
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申请号： EP88303741.8申请日： 1988-04-26
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公开(公告)号： EP0289262A3公开(公告)日： 1989-05-31
- 发明人: Venuti, Michael C. , Young, John M.
- 申请人： SYNTEX PHARMACEUTICALS INTERNATIONAL LIMITED
- 申请人地址： Corner House Church Street Hamilton 5 BM
- 专利权人： SYNTEX PHARMACEUTICALS INTERNATIONAL LIMITED
- 当前专利权人： SYNTEX PHARMACEUTICALS INTERNATIONAL LIMITED
- 当前专利权人地址： Corner House Church Street Hamilton 5 BM
- 代理机构： Armitage, Ian Michael
- 优先权： US43072 19870427
- 主分类号： C07C93/00
- IPC分类号： C07C93/00 ; C07C153/00 ; C07C93/20 ; C07C149/40 ; C07C101/50 ; C07C101/44 ; C07D209/26 ; C07D207/337 ; C07D263/56 ; C07D405/04 ; C07D487/04
摘要：
Quaternary ammonium alkyl esters and thioesters of acidic nonsteroidal anti-inflammatory drugs (NSAIDs) are disclosed. These esters and thioesters display the anti-inflammatory profile of the parent NSAIDs with greatly reduced gastrointestinal irritancy, providing a more favorable separation of therapeutic activity and toxicological side effects than the parent NSAIDs.
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