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公开(公告)号：EP0081580A4
公开(公告)日：1983-12-01
申请号：EP82902332
申请日：1982-06-23
IPC分类号： C07C219/14 , A61K31/235 , A61K31/24 , A61P27/02 , A61P27/06 , C07C20060101 , C07C67/00 , C07C69/76 , C07C69/78 , C07C69/88 , C07C213/00 , C07C101/50 , C07C101/52 , C07C101/54 , C07C101/56
CPC分类号： A61K31/235 , Y10S514/913
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2.发明公开Omega-quaternary ammonium alkyl esters and thioesters of acidic nonsteroidal antiinflammatory drugs 失效欧米茄 - 烷基酯和硫代酯von sauren nichtsteroidenentzündungshemmendenMitteln。
公开(公告)号：EP0289262A2
公开(公告)日：1988-11-02
申请号：EP88303741.8
申请日：1988-04-26
发明人： Venuti, Michael C. , Young, John M.
IPC分类号： C07C93/00 , C07C153/00 , C07C93/20 , C07C149/40 , C07C101/50 , C07C101/44 , C07D209/26 , C07D207/337 , C07D263/56 , C07D405/04 , C07D487/04
CPC分类号： C07D207/337 , C07D209/28 , C07D263/57 , C07D491/04
摘要： Quaternary ammonium alkyl esters and thioesters of acidic nonsteroidal anti-inflammatory drugs (NSAIDs) are disclosed. These esters and thioesters display the anti-inflammatory profile of the parent NSAIDs with greatly reduced gastrointestinal irritancy, providing a more favorable separation of therapeutic activity and toxicological side effects than the parent NSAIDs.
摘要翻译： 公开了酸性非甾体抗炎药（NSAID）的季铵烷基酯和硫酯。 这些酯和硫酯显示出具有大大降低的胃肠道刺激性的亲本NSAIDs的抗炎特征，提供比母体NSAID更有利的治疗活性和毒理学副作用的分离。
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公开(公告)号：EP0065964A4
公开(公告)日：1983-04-06
申请号：EP81903190
申请日：1981-11-16
IPC分类号： C07C219/14 , C07C67/00 , C07C213/00 , C07C213/08 , C07C227/00 , C07C227/02 , C07C227/18 , C07C229/22 , C07C229/60 , C07C231/00 , C07C231/12 , C07C233/25 , C07C233/54 , C07C253/00 , C07D213/00 , C07D213/30 , C07D309/12 , C07C69/017 , A61K31/22 , A61K31/24 , C07C69/76 , C07C69/78 , C07C79/46 , C07C79/48 , C07C101/30 , C07C101/50 , C07C121/52 , C07C121/60
CPC分类号： C07D213/30 , C07D309/12
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4.发明公开Complexes of bivalent copper, methods of preparation thereof and compositions containing said complexes 失效二价铜络合物，其制备方法和含有这种复合体的组合物。
公开(公告)号：EP0002341A1
公开(公告)日：1979-06-13
申请号：EP78300671.1
申请日：1978-11-27
IPC分类号： C07C65/10 , C07C101/50 , C07C149/40 , C07C163/00 , C07D239/48 , A61K31/60
CPC分类号： C07D239/42 , C07C65/10 , C07D239/48 , C07F1/005
摘要： Neutralcopper complexes, particularly copper-salicylate complexes.having the formula Cu[C 6 H 4 (OH)COO] 2 ROH in which ROH represents an alkanol, have been found to have therapeutic activity in the treatment of inflammatory diseases. The complexes have been found particularly suitable for the treatment of arthritis.
摘要翻译： 中性铜络合物，具有下式的Cu [C6H4（OH）COO]特别是铜 - 水杨酸络合物2 ROH，其中ROH darstellt烷醇的，已发现在炎性疾病的治疗中的治疗活性。 复合物已被发现特别适用于治疗关节炎。
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5.发明公开
公开(公告)号：EP0289262A3
公开(公告)日：1989-05-31
申请号：EP88303741.8
申请日：1988-04-26
发明人： Venuti, Michael C. , Young, John M.
IPC分类号： C07C93/00 , C07C153/00 , C07C93/20 , C07C149/40 , C07C101/50 , C07C101/44 , C07D209/26 , C07D207/337 , C07D263/56 , C07D405/04 , C07D487/04
CPC分类号： C07D207/337 , C07D209/28 , C07D263/57 , C07D491/04
摘要： Quaternary ammonium alkyl esters and thioesters of acidic nonsteroidal anti-inflammatory drugs (NSAIDs) are disclosed. These esters and thioesters display the anti-inflammatory profile of the parent NSAIDs with greatly reduced gastrointestinal irritancy, providing a more favorable separation of therapeutic activity and toxicological side effects than the parent NSAIDs.
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6.发明授权Complexes of bivalent copper, methods of preparation thereof and compositions containing said complexes 失效复合铜复合物，其制备方法和含有复合物的组合物
公开(公告)号：EP0002341B1
公开(公告)日：1982-01-20
申请号：EP78300671.1
申请日：1978-11-27
IPC分类号： C07C65/10 , C07C101/50 , C07C149/40 , C07C163/00 , C07D239/48 , A61K31/60
CPC分类号： C07D239/42 , C07C65/10 , C07D239/48 , C07F1/005
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公开(公告)号：EP0081580B1
公开(公告)日：1987-04-22
申请号：EP82902332.4
申请日：1982-06-23
IPC分类号： C07C101/42 , C07C101/50 , C07C101/52 , C07C101/54 , C07C101/56 , C07C69/76 , C07C69/78 , C07C69/88
CPC分类号： A61K31/235 , Y10S514/913
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公开(公告)号：EP0065964B1
公开(公告)日：1985-10-23
申请号：EP81903190.7
申请日：1981-11-16
IPC分类号： C07C69/017 , C07C69/76 , C07C69/78 , C07C79/46 , C07C79/48 , C07C101/30 , C07C101/50 , C07C121/52 , C07C121/60 , A61K31/22 , A61K31/24
CPC分类号： C07D213/30 , C07D309/12
摘要： A method for the treatment or prophylaxis of cardiac disorders in a mammal, comprising administering to such mammal a short-acting ss-blocking compound of the formula: (FORMULA) wherein X is an ester-containing group; R may be lower alkyl, aralkyl or an ester-containing group; R u may be lower alkyl; and Ar may be substituted or unsubstituted aromatic; or a pharmaceutically acceptable salt thereof. Novel compounds possessing short acting ss-adrenergic blocking activity are also disclosed.
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