发明公开
EP0304888A1 Sulfonamidolphenyl derivates and therapeutic and preventive agents for arrythmia containing same
失效
Sulfonamidolphenyl衍生物和作用于心律失常那些含有治疗和预防剂。
- 专利标题： Sulfonamidolphenyl derivates and therapeutic and preventive agents for arrythmia containing same
- 专利标题（中）： Sulfonamidolphenyl衍生物和作用于心律失常那些含有治疗和预防剂。
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申请号： EP88113786.3申请日： 1988-08-24
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公开(公告)号： EP0304888A1公开(公告)日： 1989-03-01
- 发明人: Oinuma, Hitoshi , Yamanaka, Motosuke , Miyake, Kazutoshi , Hoshiko, Tomonori , Minami, Norio , Shoji, Tadao , Daiku, Yoshiharu , Sawada, Kohei , Nomoto, Kenichi
- 申请人： Eisai Co., Ltd.
- 申请人地址： 6-10, Koishikawa 4-chome Bunkyo-ku Tokyo 112 JP
- 专利权人： Eisai Co., Ltd.
- 当前专利权人： Eisai Co., Ltd.
- 当前专利权人地址： 6-10, Koishikawa 4-chome Bunkyo-ku Tokyo 112 JP
- 代理机构： Hansen, Bernd, Dr.rer.nat.
- 优先权： JP209726/87 19870824; JP209727/87 19870824; JP209728/87 19870824
- 主分类号： C07D211/54
- IPC分类号： C07D211/54 ; C07D401/06 ; C07D213/38 ; C07D211/32 ; C07D211/14 ; C07C311/08 ; A61K31/44 ; A61K31/445 ; A61K31/18
摘要：
Piperidine compounds of general formula (XX) are provided which are useful as medicaments for the treatment or prophylaxis of arrhythmia.
in which R¹ is a lower alkyl and W is:
wherein X is -S-, -SO- or -SO₂-; R² is hydrogen or -(CH₂) n -Y; n is an integer of 1 to 5; Y is an aryl, pyridyl or a substituted pyridyl group; X′ is -CO- or -CH(OH)-; p is an integer of 1 to 4; R¹² is hydrogen or a lower alkyl group; Y′ is -(CH₂) m -A; m is 1 or 2; A is an aryl, a substituted aryl, pyridyl or a substituted pyridyl group; R¹² and Y may form a 5- or 6-membered ring or a 5- or 6-membered ring having one or more substituents; and R²² is hydrogen, a halogen, a lower alkyl, a lower alkoxy or hydroxy.
in which R¹ is a lower alkyl and W is:
wherein X is -S-, -SO- or -SO₂-; R² is hydrogen or -(CH₂) n -Y; n is an integer of 1 to 5; Y is an aryl, pyridyl or a substituted pyridyl group; X′ is -CO- or -CH(OH)-; p is an integer of 1 to 4; R¹² is hydrogen or a lower alkyl group; Y′ is -(CH₂) m -A; m is 1 or 2; A is an aryl, a substituted aryl, pyridyl or a substituted pyridyl group; R¹² and Y may form a 5- or 6-membered ring or a 5- or 6-membered ring having one or more substituents; and R²² is hydrogen, a halogen, a lower alkyl, a lower alkoxy or hydroxy.
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