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1205 条记录 (耗时 0.029 秒)

    DIHYDROPYRIDINE COMPOUNDS FOR NEURODEGENERATIVE DISEASES AND DEMENTIA
    2.
    发明公开
    DIHYDROPYRIDINE COMPOUNDS FOR NEURODEGENERATIVE DISEASES AND DEMENTIA 有权
    二氢吡啶LINKS神经退行性疾病和老年痴呆症

    公开(公告)号：EP1871368A2

    公开(公告)日：2008-01-02

    申请号：EP06740387.3

    申请日：2006-04-04

    申请人： Eisai Co., Ltd.

    发明人： GRAY, Julian, A. ,  YOSHIHARU, Yamanishi ,  NOBUYUKI, Mori ,  FIELDS, Scott

    IPC分类号： A61K31/445 ,  A61K31/444

    CPC分类号： A61K31/4412 ,  A61K31/444 ,  A61K31/445 ,  A61K2300/00

    摘要： The invention provides methods for treating and/or preventing cognitive impairments, dementia, or neurodegenerative diseases and disorders (e.g., Alzheimer's disease, Parkinson's disease, Huntington's disease, amyotrophic lateral sclerosis) in patients by administering therapeutically effective amounts of an AMPA receptor antagonist (e.g., 1,2-dihydropyridine compounds) and therapeutically effective amounts of nootropics (e.g., cholinesterase inhibitors) to patients. The invention also provides combinations, commercial packages, and pharmaceutical compositions comprising therapeutically effective amounts of AMPA receptor antagonists (e.g., 1,2- dihydropyridine compounds) and therapeutically effective amounts nootropics (e.g., cholinesterase inhibitors). The 1,2-dihydropyridine compound may be, for example, 3- (2-cyanophenyl)-5-(2-pyridyl)-l-phenyl-l,2-dihydropyridin-2-one. The cholinesterase inhibitor may be, for example, donepezil.

    SOFT CAPSULE PREPARATION
    6.
    发明公开
    SOFT CAPSULE PREPARATION 审中-公开
    WEICHKAPSELZUBEREITUNG

    公开(公告)号：EP1721619A1

    公开(公告)日：2006-11-15

    申请号：EP05719165.2

    申请日：2005-02-16

    申请人： Eisai Co., Ltd.

    发明人： MOMOI, Kazuhisa, c/o EISAI CO., LTD.

    IPC分类号： A61K47/24 ,  A23L1/00 ,  A61J3/07 ,  A61K9/48

    CPC分类号： A61K9/4883 ,  A23P10/30 ,  A61K47/24

    摘要： It is an object of the present invention to provide a capsule anti-sticking agent which can provide excellent anti-sticking effect on a soft capsule without impairing various properties such as water activity, disintegration property and safety, a coated soft capsule of high quality which is coated with the capsule anti-sticking agent and excels in anti-sticking effect, and an efficient method for manufacturing the coated soft capsule.
    The present invention includes a capsule anti-sticking agent containing an enzymatically decomposed lecithin, a coated soft capsule wherein a surface is coated with the capsule anti-sticking agent, and a method for manufacturing the coated soft capsule in which a surface of a soft capsule is coated with the capsule anti-sticking agent.

    摘要翻译： 本发明的目的是提供一种胶囊防粘剂，其可以在不损害诸如水分活度，崩解性和安全性等各种性能的情况下对软胶囊提供优异的抗粘连作用，高质量的涂覆软胶囊 涂有胶囊防粘剂，抗粘着性好，是涂膜软胶囊的制造方法。 本发明包括含有酶促分解的卵磷脂的胶囊防粘剂，其中表面涂敷有胶囊防粘剂的被覆软胶囊，以及软胶囊的表面的制造方法 涂有胶囊防粘剂。

    DNA PARTICIPATING IN HYDROXYLATION OF MACROLIDE COMPOUND
    8.
    发明公开
    DNA PARTICIPATING IN HYDROXYLATION OF MACROLIDE COMPOUND 审中-公开
    ER ER UNG UNG E E E E E E E E E E E DNA E

    公开(公告)号：EP1705247A1

    公开(公告)日：2006-09-27

    申请号：EP04799902.4

    申请日：2004-11-25

    申请人： MERCIAN CORPORATION ,  Eisai Co., Ltd.

    发明人： MACHIDA, Kazuhiro ,  NAKASHIMA, Takashi ,  ARITOKU, Yasuhide ,  TSUCHIDA, Toshio

    IPC分类号： C12N15/09 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12N9/02 ,  C12P17/08 ,  C07K14/00

    CPC分类号： C12P17/08 ,  C12N9/10

    摘要： The present invention provides a DNA participating in biological transformation of a macrolide compound 11107B. The present invention provides, paticularly, a DNA participating in biological transformation of a macrolide compound 11107B represented by the formula (I) into a 16-position hydroxy macrolide compound 11107D represented by the formula (II), the DNA encoding a protein having 16-position hydroxylating enzymatic activity or ferredoxin, to a method of isolating the DNA, to a protein encoded by the DNA, a plasmid carrying the DNA, a transformant obtained by transforming using the plasmid and a method of producing a 16-position hydroxy compound by using the transformant.

    摘要翻译： 本发明提供参与大环内酯化合物11107B的生物转化的DNA。 本发明特别提供参与由式（I）表示的大环内酯化合物11107B的生物转化成由式（II）表示的16位羟基大环内酯化合物11107D的DNA，编码具有16位的式 位置羟化酶活性或铁氧还蛋白，分离DNA的方法，由DNA编码的蛋白质，携带DNA的质粒，通过使用质粒转化获得的转化体和通过使用制备16位羟基化合物的方法 转化体。

    MAGNETIC CELL AND METHOD OF USING THE SAME
    10.
    发明公开
    MAGNETIC CELL AND METHOD OF USING THE SAME 有权
    MAGNETISCHE ZELLE UND VERFAHREN ZUR VERWENDUNG DAVON

    公开(公告)号：EP1650293A4

    公开(公告)日：2006-07-26

    申请号：EP04746441

    申请日：2004-06-25

    申请人： EISAI CO LTD ,  OCHI MITSUO

    发明人： OCHI MITSUO

    IPC分类号： C12N5/00

    CPC分类号： C12N5/0006 ,  A61K41/00 ,  A61K47/6901

    摘要： No example of binding of magnetic particles to mesenchymal cell, chondrocyte and other cells whose use in regenerative medicine, etc. can be expected is known. Thus, whether or not cells having magnetic particles bound thereto after administration are retained in local by outside magnetism and whether or not the cells can exhibit the intrinsic activity are studied. In particular, there are provided magnetic cells comprising mesenchymal cells or chondral cultured cells having magnetic particles bound to the surface thereof, which magnetic cells are administered into a body. The magnetic cells can be retained in a seat of disease for a prolonged period of time by applying magnetic field from outside. Further, a drug delivery system can be constructed by causing the magnetic cells to contain drugs.

    摘要翻译： 已知没有磁性颗粒与用于再生医学等的间充质细胞，软骨细胞和其他细胞结合的实例。 因此，研究了施用后具有与之结合的磁性颗粒的细胞是否通过外部磁力保留在局部，以及细胞是否能显示内在活性。 具体而言，提供了包含间充质细胞或具有与其表面结合的磁性颗粒的软骨培养细胞的磁性细胞，该磁性细胞被施用到体内。 通过施加来自外部的磁场，可将磁性细胞长时间保留在疾病位置。 此外，可以通过使磁性细胞含有药物来构建药物递送系统。