发明公开
EP0307853A2 Method for the production of ribavirin using high ribose donor concentrations
失效
Verfahren zur Herstellung von Ribavirin unter Verwendung von hohen Ribose-Donor-Konzentrationen。
- 专利标题： Method for the production of ribavirin using high ribose donor concentrations
- 专利标题（中）： Verfahren zur Herstellung von Ribavirin unter Verwendung von hohen Ribose-Donor-Konzentrationen。
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申请号： EP88114937.1申请日： 1988-09-13
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公开(公告)号： EP0307853A2公开(公告)日： 1989-03-22
- 发明人: Pochodylo, James Michael
- 申请人： GENENCOR INTERNATIONAL, INC.
- 申请人地址： 180 Kimball Way South San Francisco, CA 94080 US
- 专利权人： GENENCOR INTERNATIONAL, INC.
- 当前专利权人： GENENCOR INTERNATIONAL, INC.
- 当前专利权人地址： 180 Kimball Way South San Francisco, CA 94080 US
- 代理机构： Brandes, Jürgen, Dr.
- 优先权： US97767 19870917
- 主分类号： C12P19/28
- IPC分类号： C12P19/28
摘要：
A method for the production of a 1,2,4-triazole nucleoside comprising the step of reacting a ribose donor with a triazole compound in the presence of an enzyme preparation derived from Brevibacterium acetylicum is disclosed. The method is characterized in that the ribose donor is guanosine; the concentration of the donor is above 100 mM; and the enzyme preparation is added before the reaction mixture gells. The method is capable of high production rates and high concentrations of the final product.
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