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1.发明公开Method for the production of ribavirin using high ribose donor concentrations 失效Verfahren zur Herstellung von Ribavirin unter Verwendung von hohen Ribose-Donor-Konzentrationen。
公开(公告)号：EP0307853A2
公开(公告)日：1989-03-22
申请号：EP88114937.1
申请日：1988-09-13
IPC分类号： C12P19/28
CPC分类号： C12P19/38 , Y10S435/84
摘要： A method for the production of a 1,2,4-triazole nucleoside comprising the step of reacting a ribose donor with a triazole compound in the presence of an enzyme preparation derived from Brevibacterium acetylicum is disclosed. The method is characterized in that the ribose donor is guanosine; the concentration of the donor is above 100 mM; and the enzyme preparation is added before the reaction mixture gells. The method is capable of high production rates and high concentrations of the final product.
摘要翻译： 公开了一种制备1,2,4-三唑核苷的方法，包括在衍生自乙酰微小杆菌的酶制剂存在下使核糖供体与三唑化合物反应的步骤。 该方法的特征在于核糖供体是鸟苷; 供体的浓度高于100mM; 在反应混合物凝胶化之前加入酶制剂。 该方法具有高生产率和高浓度的最终产品。
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2.发明授权
公开(公告)号：EP0307853B1
公开(公告)日：1992-12-09
申请号：EP88114937.1
申请日：1988-09-13
IPC分类号： C12P19/28
CPC分类号： C12P19/38 , Y10S435/84
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3.发明公开
公开(公告)号：EP0307853A3
公开(公告)日：1990-05-02
申请号：EP88114937.1
申请日：1988-09-13
IPC分类号： C12P19/28
CPC分类号： C12P19/38 , Y10S435/84
摘要： A method for the production of a 1,2,4-triazole nucleoside comprising the step of reacting a ribose donor with a triazole compound in the presence of an enzyme preparation derived from Brevibacterium acetylicum is disclosed. The method is characterized in that the ribose donor is guanosine; the concentration of the donor is above 100 mM; and the enzyme preparation is added before the reaction mixture gells. The method is capable of high production rates and high concentrations of the final product.
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