发明公开
EP0311010A3 Alpha,Alpha-disubstituted aromatics and heteroaromatics as cognition enhancers
失效
阿尔法，α-二取代芳烃和杂芳烃作为认知增强剂
- 专利标题： Alpha,Alpha-disubstituted aromatics and heteroaromatics as cognition enhancers
- 专利标题（中）： 阿尔法，α-二取代芳烃和杂芳烃作为认知增强剂
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申请号： EP88116393.5申请日： 1988-10-04
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公开(公告)号： EP0311010A3公开(公告)日： 1991-01-30
- 发明人: Earl, Richard Alan , Myers, Melvyn John , Nickolson, Victor Johannes
- 申请人： THE DU PONT MERCK PHARMACEUTICAL COMPANY
- 申请人地址： Barley Mill Plaza, Building 25 Wilmington, Delaware 19880-0025 US
- 专利权人： THE DU PONT MERCK PHARMACEUTICAL COMPANY
- 当前专利权人： THE DU PONT MERCK PHARMACEUTICAL COMPANY
- 当前专利权人地址： Barley Mill Plaza, Building 25 Wilmington, Delaware 19880-0025 US
- 代理机构： von Kreisler, Alek, Dipl.-Chem.
- 优先权： US105156 19871006; US234382 19880823
- 主分类号： C07D401/14
- IPC分类号： C07D401/14 ; C07D403/14 ; C07D213/16 ; C07D213/30 ; C07D405/14 ; C07D213/50 ; C07D213/26 ; C07D409/14 ; C07D213/38 ; C07D213/40 ; C07D471/04
摘要：
Cognitive defeciencies or neurological dysfunction in mammals are treated with α,α-disubstituted aromatic or heteroaromatic compounds. The compounds have the formula:
or a salt thereof
wherein X and Y are taken together to form a saturated or unsaturated carbocyclic or heterocyclic first ring and the shown carbon in said ring is a to at least one additional aromatic ring or heteroaromatic ring fused to the first ring;
one of Het' or Het 2 is 2, 3, or 4-pyridyl or 2, 4, or 5-pyrimidinyl and the other is selected from
(a) 2, 3, or 4-pyridyl, (b) 2, 4, or 5-pyrimidinyl, (c) 2-pyrazinyl, (d) 3, or 4-pyridazinyl, (e) 3, or 4-pyrazolyl, (f) 2, or 3-tetrahydrofuranyl, and (g) 3-thienyl.
or a salt thereof
wherein X and Y are taken together to form a saturated or unsaturated carbocyclic or heterocyclic first ring and the shown carbon in said ring is a to at least one additional aromatic ring or heteroaromatic ring fused to the first ring;
one of Het' or Het 2 is 2, 3, or 4-pyridyl or 2, 4, or 5-pyrimidinyl and the other is selected from
(a) 2, 3, or 4-pyridyl, (b) 2, 4, or 5-pyrimidinyl, (c) 2-pyrazinyl, (d) 3, or 4-pyridazinyl, (e) 3, or 4-pyrazolyl, (f) 2, or 3-tetrahydrofuranyl, and (g) 3-thienyl.
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