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    METHOD FOR PRODUCING AROMATIC HETEROCYCLIC RING-SUBSTITUTED DIFLUOROACETIC ACID DERIVATIVE
    1.
    发明公开
    METHOD FOR PRODUCING AROMATIC HETEROCYCLIC RING-SUBSTITUTED DIFLUOROACETIC ACID DERIVATIVE 审中-公开

    公开(公告)号：EP4101843A1

    公开(公告)日：2022-12-14

    申请号：EP21750438.0

    申请日：2021-02-03

    申请人： AGC INC.

    发明人： NOMURA, Yoshitaka ,  ANRAKU, Eiichiro

    IPC分类号： C07D213/26 ,  C07D215/16 ,  C07D233/26 ,  C07D237/30 ,  C07D241/44 ,  C07D277/64

    摘要： The aim of the present invention is to provide a method capable of easily and inexpensively producing aromatic heterocycle-substituted difluoroacetic acid derivatives.
    The present invention relates to a method for producing an aromatic heterocycle-substituted difluoroacetic acid derivative having a partial structure represented by the formula (III), which comprises reacting an N-oxido aromatic heterocyclic compound having a partial structure represented by the formula (I) with tetrafluoroethylene in the presence of a compound represented by the formula (II): R-YH, in a solvent selected from an aromatic hydrocarbon solvent, an ester solvent and an ether solvent.

    wherein each symbol is as described in the description.

    METHOD FOR PREPARATION OF 2-CHLORO-5-TRIFLUOROMETHYLPYRIDINE
    3.
    发明公开
    METHOD FOR PREPARATION OF 2-CHLORO-5-TRIFLUOROMETHYLPYRIDINE 审中-公开

    公开(公告)号：EP3696168A1

    公开(公告)日：2020-08-19

    申请号：EP18898437.1

    申请日：2018-12-05

    申请人： Zhejiang Lantian Environmental Protection Hi-Tech Co., Ltd. ,  Zhejiang Research Institute of Chemical Industry Co., Ltd. ,  Sinochem Lantian Co., Ltd.

    发明人： YU, Wanjin ,  LIN, Shengda ,  LIU, Minyang ,  LIU, Wucan ,  ZHANG, Jianjun ,  CHEN, Xianjin

    IPC分类号： C07D213/61 ,  C07D213/26

    摘要： The present invention provides a method for the preparing of 2-chloro-5-trifluoromethylpyridine, comprising two steps of chlorofluorination reaction and chlorination reaction, the chlorination catalyst used in the chlorination reaction was chosen from a fluoride, an oxide, a hydroxide, a carbonate, or a chloride of magnesium, calcium and barium and a supported palladium catalyst; or under the action of at least one catalyst chosen from ZSM-5, 5A, β and 13X molecular sieves, 3-trifluoromethylpyridine and chlorine gas phase have reaction to obtain 2-chloro-5-trifluoromethylpyridine. Or, under the action of a catalyst chosen from a fluoride, an oxide, a hydroxide, a carbonate, or a chloride of magnesium, calcium, and barium and a supported palladium catalyst, 3-trifluoromethylpyridine and chlorine gas phase have reaction to obtain 2-chloro-5-trifluoromethylpyridine. The present invention has the advantages of easily availability and low-cost of raw materials, safe operation, high yield, easy isolation and recovery of catalyst, environmental protection, fast reaction speed and continuous production on a large-scale, etc.