发明公开
- 专利标题： Pyridylthiazolidine carboxamide derivatives and their intermediates and production of both
- 专利标题（中）： 吡咯烷酮羧酰胺衍生物及其中间体和两者的生产
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申请号： EP89303137.7申请日： 1989-03-30
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公开(公告)号： EP0350145A3公开(公告)日： 1990-07-04
- 发明人: Mase, Toshiyasu , Hara, Hiromu , Yamada, Toshimitsu
- 申请人： YAMANOUCHI PHARMACEUTICAL CO. LTD.
- 申请人地址： No. 3-11 Nihonbashi-Honcho, 2-chome Chuo-ku Tokyo JP
- 专利权人： YAMANOUCHI PHARMACEUTICAL CO. LTD.
- 当前专利权人： YAMANOUCHI PHARMACEUTICAL CO. LTD.
- 当前专利权人地址： No. 3-11 Nihonbashi-Honcho, 2-chome Chuo-ku Tokyo JP
- 代理机构： Geering, Keith Edwin
- 优先权： JP108743/88 19880428
- 主分类号： C07D295/10
- IPC分类号： C07D295/10 ; C07D417/04 ; C07D417/14 ; A61K31/425
摘要：
This invention provides pyridylthiazolidine carboxamide derivatives shown by general formula (I) and pharmaceutically acceptable salts thereof:
wherein A¹ is a single bond, carbonyl group or lower alkylene group which may include a carbonyl group and R¹ is a heterocyclic ring which may be substituted with a lower alkyl group; it further provides N-substituted piperazine derivatives useful as intermediates for preparing said compounds (I). Compounds (I) and their salts have PAF-antagonistic activity.
wherein A¹ is a single bond, carbonyl group or lower alkylene group which may include a carbonyl group and R¹ is a heterocyclic ring which may be substituted with a lower alkyl group; it further provides N-substituted piperazine derivatives useful as intermediates for preparing said compounds (I). Compounds (I) and their salts have PAF-antagonistic activity.
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