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    (Substituted benzyl)-thio heterocyclic compounds having a leukotriene-antagonist activity
    9.
    发明公开
    (Substituted benzyl)-thio heterocyclic compounds having a leukotriene-antagonist activity 失效
    （取代苄基） - 十二烷基杂环化合物具有亮氨酸 - 拮抗剂活性

    公开(公告)号：EP0214732A3

    公开(公告)日：1988-01-13

    申请号：EP86305633

    申请日：1986-07-22

    申请人： YAMANOUCHI PHARMACEUTICAL CO. LTD.

    发明人： Mase, Toshiyasu ,  Murase, Kiyoshi ,  Tsuzuki, Ryuji ,  Tomioka, Kenichi ,  Hara, Hiromu

    IPC分类号： C07D285/12 ,  C07D239/56 ,  C07D213/70 ,  C07D249/12 ,  C07D275/02 ,  A61K31/41 ,  A61K31/44 ,  A61K31/505

    CPC分类号： C07D213/70 ,  C07D239/56 ,  C07D249/12 ,  C07D275/03 ,  C07D285/125 ,  C07D285/135

    摘要： Heterocyclic compound of formula (I) and salts thereof are SRS-A antagonists:
    wherein R' is a C 1 to C 8 acyl group; R 2 is a C 1 to C a alkyl group; Het- is a 5- or 6-membered heterocyclic ring which contains 1 to 3 nitrogen atoms and may additionally contain a sulfur atom or an oxygen atom; R 3 is a carboxy group, an amino group, a C 1 to C 8 alkylamino group which may be carboxy-substituted, a C, to C 8 alkanoylamino group which may be carboxy-substituted, a di-(C 1 -C 8 alkyl) amino group, a hydroxy group, a C 1 to C 8 alkoxy group which may be carboxy-substituted, a mercapto group, a C 1 -C 8 alkylthio group which may be carboxy-substituted, a group of formula:
    or formula:
    (wherein p is integer of 1 to 5, q is 0, 1 or 2, r is an integer of 1 to 5; R 4 is a carboxy group, a C 1 -C 8 alkoxy group which may be carboxy-substituted or a C 1 -C 8 alkyl group which may be carboxy-substituted and optionally additionally contain a sulfur atom or an oxygen atom in the carbon chain thereof); and n is 0 or an integer of to 3; provided that when the compound is substituted by a carboxy group, said carboxy group may be in the form of an ester, and when n is 2 or 3 different R 3 's is may be present.