发明公开
EP0352832A1 Compounds with bronchodilator activity
失效
Verbindungen mit bronchodilatatorischerAktivität。
- 专利标题： Compounds with bronchodilator activity
- 专利标题（中）： Verbindungen mit bronchodilatatorischerAktivität。
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申请号： EP89201621.3申请日： 1989-06-21
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公开(公告)号： EP0352832A1公开(公告)日： 1990-01-31
- 发明人: Logan, Robert Thomas , McGarry, George , Roy, Robert Gibson , Redpath, James
- 申请人： AKZO N.V.
- 申请人地址： Velperweg 76 NL-6824 BM Arnhem NL
- 专利权人： AKZO N.V.
- 当前专利权人： AKZO N.V.
- 当前专利权人地址： Velperweg 76 NL-6824 BM Arnhem NL
- 代理机构： Hermans, Franciscus G.M.
- 优先权： EP88306121 19880705
- 主分类号： A61K31/38
- IPC分类号： A61K31/38 ; A61K31/34 ; A61K31/15 ; A61K31/155 ; C07D333/58 ; C07D333/70 ; C07D307/81 ; C07D307/85 ; C07C251/32
摘要：
A method is provided for treating patients suffering from or susceptible to bronchoconstriction, particularly for patients suffering from an asthmatic attack which comprises the use of benzothiophene, benzofuran, dihydronaphthalene or indene derivatives represented by formula I
wherein each of R¹, R², R³ and R⁴ is independently H, (1-4C) alkyl, (1-4C) halogen substituted alkyl, OH, (1-4C) alkoxy, (1-4C) halogen substituted alkoxy, NO₂, CN, halogen, an unsubstituted or (1-4C) alkyl substituted amino group, or wherein two adjacent groups R¹, R², R³ or R⁴ together form methylenedioxy;
X is S, O or (CH₂) m in which m is 1 or 2;
R⁵ is H or (1-4C) alkyl;
R⁶ is H, NH₂ or (1-4C) alkyl;
R⁷ is H, (1-4C) alkyl or OR⁸ in which
R⁸ is H, (1-4C) alkyl or (1-8C) acyl;
and its pharmaceutically acceptable salts for the prepa ration of a medicament with bronchodilator activity.
wherein each of R¹, R², R³ and R⁴ is independently H, (1-4C) alkyl, (1-4C) halogen substituted alkyl, OH, (1-4C) alkoxy, (1-4C) halogen substituted alkoxy, NO₂, CN, halogen, an unsubstituted or (1-4C) alkyl substituted amino group, or wherein two adjacent groups R¹, R², R³ or R⁴ together form methylenedioxy;
X is S, O or (CH₂) m in which m is 1 or 2;
R⁵ is H or (1-4C) alkyl;
R⁶ is H, NH₂ or (1-4C) alkyl;
R⁷ is H, (1-4C) alkyl or OR⁸ in which
R⁸ is H, (1-4C) alkyl or (1-8C) acyl;
and its pharmaceutically acceptable salts for the prepa ration of a medicament with bronchodilator activity.
公开/授权文献
- EP0352832B1 Compounds with bronchodilator activity 公开/授权日：1992-05-06
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