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8 条记录 (耗时 0.009 秒)

    Indene and naphthalene derivatives
    5.
    发明公开
    Indene and naphthalene derivatives 失效
    IN-UND Naphthalinderivate。

    公开(公告)号：EP0199393A1

    公开(公告)日：1986-10-29

    申请号：EP86200495.9

    申请日：1986-03-24

    申请人： AKZO N.V.

    发明人： Logan, Robert Thomas ,  Redpath, James ,  Roy, Robert Gibson

    IPC分类号： C07C83/10 ,  C07C123/00 ,  C07C133/12 ,  C07C135/00 ,  A61K31/155

    CPC分类号： C07C259/18 ,  C07C281/18

    摘要： The invention relates to compounds of the general formula I
    wherein

    R 1 represents one up to and including four, the same or different substituents selected from alkyl- (1-6 C), alkoxy(1-6 C), hydroxy, halogen, NO 2 , CF 3 or the group -NR 5 R 6 ,
    whereby two substituents taken together may also represent a methylene-dioxy group,
    X represents a member selected from

    , -CH 2 -CH 2 -and -CH=CH-.
    n has the value 0, 1 or 2,
    R 3 represents one of the moieties:
    or
    and R 2 , R 4 , R s and R 6 represent hydrogen or alkyl-(1-6C),
    and pharmaceutically acceptable salts thereof, suitable in the treatment of heartfailure.

    Compounds with bronchodilator activity
    6.
    发明公开
    Compounds with bronchodilator activity 失效
    Verbindungen mit bronchodilatatorischerAktivität。

    公开(公告)号：EP0352832A1

    公开(公告)日：1990-01-31

    申请号：EP89201621.3

    申请日：1989-06-21

    申请人： AKZO N.V.

    发明人： Logan, Robert Thomas ,  McGarry, George ,  Roy, Robert Gibson ,  Redpath, James

    IPC分类号： A61K31/38 ,  A61K31/34 ,  A61K31/15 ,  A61K31/155 ,  C07D333/58 ,  C07D333/70 ,  C07D307/81 ,  C07D307/85 ,  C07C251/32

    CPC分类号： C07D333/58 ,  A61K31/15 ,  A61K31/155 ,  A61K31/34 ,  A61K31/38 ,  C07C259/16 ,  C07D307/81 ,  C07D307/85 ,  C07D333/70 ,  Y10S514/826

    摘要： A method is provided for treating patients suffering from or susceptible to bronchoconstriction, particularly for patients suffering from an asthmatic attack which comprises the use of benzothiophene, benzofuran, dihydronaphthalene or indene derivatives represented by formula I
    wherein each of R¹, R², R³ and R⁴ is independently H, (1-­4C) alkyl, (1-4C) halogen substituted alkyl, OH, (1-4C) alkoxy, (1-4C) halogen substituted alkoxy, NO₂, CN, halogen, an unsubstituted or (1-4C) alkyl substituted amino group, or wherein two adjacent groups R¹, R², R³ or R⁴ together form methylenedioxy;
    X is S, O or (CH₂) m in which m is 1 or 2;
    R⁵ is H or (1-4C) alkyl;
    R⁶ is H, NH₂ or (1-4C) alkyl;
    R⁷ is H, (1-4C) alkyl or OR⁸ in which
    R⁸ is H, (1-4C) alkyl or (1-8C) acyl;
    and its pharmaceutically acceptable salts for the prepa ration of a medicament with bronchodilator activity.

    摘要翻译： 提供了一种治疗患有或易患支气管收缩的患者的方法，特别是患有哮喘发作的患者，其中包括使用由式I 表示的苯并噻吩，苯并呋喃，二氢萘或茚衍生物，其中R 1， R 2，R 3和R 4独立地是H，（1-4C）烷基，（1-4C）卤素取代的烷基，OH，（1-4C）烷氧基，（1-4C） 烷氧基，NO 2，CN，卤素，未取代或（1-4C）烷基取代的氨基，或其中两个相邻基团R 1，R 2，R 3或R 4一起形成亚甲二氧基; X是S，O或（CH 2）m，其中m是1或2; R 5是H或（1-4C）烷基; R 6是H，NH 2或（1-4C）烷基; R 7是H，（1-4C）烷基或OR 8，其中R 8是H，（1-4C）烷基或（1-8C）酰基; 及其药学上可接受的盐，用于制备具有支气管扩张剂活性的药物。

    Benzobicyclononane amino derivatives with anticonvulsive properties
    8.
    发明公开
    Benzobicyclononane amino derivatives with anticonvulsive properties 失效
    Benzobicyclononanamin-Derivate mit antikonvul​​siven Eigenschaften。

    公开(公告)号：EP0124150A1

    公开(公告)日：1984-11-07

    申请号：EP84200370.9

    申请日：1984-03-14

    申请人： AKZO N.V.

    发明人： Savage, David Samuel ,  Redpath, James

    IPC分类号： A61K31/135 ,  C07C87/458

    CPC分类号： C07C211/42 ,  C07C2603/70

    摘要： The present invention relates to the use of a compound of the general formula I
    wherein R 1 and R 2 represent hydrogen or a lower alkyl group (1-4 C), preferably methyl, ethyl, propyl or isopropyl, the broken line indicates an optional extra bond, and X and Y represent hydrogen, alkyl (1-4 C) or halogen (preferably fluorine), or a pharmaceutically acceptable acid addition salt thereof, for its anticonvulsive property.

    摘要翻译： 本发明涉及通式I的化合物其中R 1和R 2代表氢或低级烷基（1-4C），优选甲基，乙基，丙基或异丙​​基，虚线表示 X和Y代表氢，烷基（1-4C）或卤素（优选氟）或其药学上可接受的酸加成盐，用于其抗惊厥性质。