发明公开
EP0353538A2 Process for the preparation of intermediates for the synthesis of diltiazem
失效
一种用于制备中的中间体的对地尔硫的合成过程。
- 专利标题： Process for the preparation of intermediates for the synthesis of diltiazem
- 专利标题（中）： 一种用于制备中的中间体的对地尔硫的合成过程。
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申请号： EP89113135.1申请日： 1989-07-18
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公开(公告)号： EP0353538A2公开(公告)日： 1990-02-07
- 发明人: Giordano, Claudio , Merli, Valeriano , Sagramora, Giorgio , Soriato, Giorgio
- 申请人： ZAMBON GROUP S.p.A.
- 申请人地址： Via della Chimica, 9 I-36100 Vicenza IT
- 专利权人： ZAMBON GROUP S.p.A.
- 当前专利权人： ZAMBON GROUP S.p.A.
- 当前专利权人地址： Via della Chimica, 9 I-36100 Vicenza IT
- 优先权： IT2147888 19880726
- 主分类号： C07C323/36
- IPC分类号： C07C323/36 ; C07C319/28 ; C07B57/00
摘要：
A process for the preparation of (2S,3S)-threo-2-hydroxy-3-(2-aminophenylthio)-3-(4-methoxyphenyl)-propionic acid by resolution of the racemic mixture is described.
The resolution is carried out by using as resolving agent (1S,2S)-threo-1-phenyl-2-amino-1,3-propanediol or (1S,2S)-threo-1-(4-methylthiophenyl)-2-amino-1,3-propanediol.
The resolution is carried out by using as resolving agent (1S,2S)-threo-1-phenyl-2-amino-1,3-propanediol or (1S,2S)-threo-1-(4-methylthiophenyl)-2-amino-1,3-propanediol.
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