发明公开
- 专利标题： Cytotoxic drug conjugates
- 专利标题（中）： 细胞毒性药物偶联物
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申请号： EP89307915.2申请日： 1989-08-03
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公开(公告)号： EP0354728A3公开(公告)日： 1991-04-10
- 发明人: Cullinan, George Joseph , Laguzza, Bennett Coleman , Scott, William Leonard
- 申请人： ELI LILLY AND COMPANY
- 申请人地址： Lilly Corporate Center Indianapolis, Indiana 46285 US
- 专利权人： ELI LILLY AND COMPANY
- 当前专利权人： ELI LILLY AND COMPANY
- 当前专利权人地址： Lilly Corporate Center Indianapolis, Indiana 46285 US
- 代理机构： Tapping, Kenneth George
- 优先权： US230084 19880808
- 主分类号： A61K47/48
- IPC分类号： A61K47/48 ; A61K39/395 ; C07D519/04
摘要：
A series of antibody-vinca drug conjugates comprise antibodies which target antigens associated with undesirable cells, so that the cells are controlled or killed by the cytotoxic vinca drug. The drug is linked to the antibody through an organic group comprising a carbonyl at the antibody end, and an alkylidene hydrazide at the vinca end.
公开/授权文献
- EP0354728A2 Cytotoxic drug conjugates 公开/授权日：1990-02-14
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