发明公开
EP0355460A3 Stabilization of somatotropins by modification of cysteine residues utilizing site directed mutagenesis or chemical derivatization
失效
通过修饰利用现场指导的突变或化学衍生物的CYSTEINE残留物来抑制SOMATOTROPINS的稳定性
- 专利标题： Stabilization of somatotropins by modification of cysteine residues utilizing site directed mutagenesis or chemical derivatization
- 专利标题（中）： 通过修饰利用现场指导的突变或化学衍生物的CYSTEINE残留物来抑制SOMATOTROPINS的稳定性
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申请号： EP89113852.1申请日： 1989-07-27
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公开(公告)号： EP0355460A3公开(公告)日： 1991-04-03
- 发明人: Cady, Susan Mancini , Logan, John Steele , Buckwalter, Brian Lee , Stockton, Gerald W. , Chaleff, Deborah Tardy
- 申请人： AMERICAN CYANAMID COMPANY
- 申请人地址： One Cyanamid Plaza Wayne, NJ 07470-8426 US
- 专利权人： AMERICAN CYANAMID COMPANY
- 当前专利权人： AMERICAN CYANAMID COMPANY
- 当前专利权人地址： One Cyanamid Plaza Wayne, NJ 07470-8426 US
- 代理机构： Wächtershäuser, Günter, Prof. Dr.
- 优先权： US236060 19880824; US372699 19890703
- 主分类号： C12N15/18
- IPC分类号： C12N15/18 ; C12P21/02 ; C07K3/08 ; A61K37/36
摘要：
The present invention relates to novel modified or derivatized recombinant animal somatotropins. This invention also provides methods for stabilizing recombinant animal somatotropins by modification or deletion of the Cysteine residues utilizing site directed mutagenesis to replace from one to four of the cysteine amino acid residues of said somatotropins with one or more different amino acid residues or by derivatization of (1) both cysteine amino acid residues in the small loop of said somatotropin, both cysteine amino acid residues in the large loop or the four cysteine amino acid residues in both loops of said somatotropin.
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