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    Stabilization of somatotropins by modification of cysteine residues utilizing site directed mutagenesis or chemical derivatization
    1.
    发明公开
    Stabilization of somatotropins by modification of cysteine residues utilizing site directed mutagenesis or chemical derivatization 失效
    生长激素由半胱氨酸残基的修饰通过定点突变或化学衍生的稳定。

    公开(公告)号：EP0355460A2

    公开(公告)日：1990-02-28

    申请号：EP89113852.1

    申请日：1989-07-27

    申请人： AMERICAN CYANAMID COMPANY

    发明人： Cady, Susan Mancini ,  Logan, John Steele ,  Buckwalter, Brian Lee ,  Stockton, Gerald W. ,  Chaleff, Deborah Tardy

    IPC分类号： C12N15/18 ,  C12P21/02 ,  C07K3/08 ,  A61K37/36

    CPC分类号： C07K1/1133 ,  A61K38/00 ,  C07K14/61

    摘要： The present invention relates to novel modified or derivatized recombinant animal somatotropins. This invention also provides methods for stabilizing recombinant animal somatotropins by modification or deletion of the Cysteine residues utilizing site directed mutagenesis to replace from one to four of the cysteine amino acid residues of said somatotropins with one or more different amino acid residues or by derivatization of (1) both cysteine amino acid residues in the small loop of said somatotropin, both cysteine amino acid residues in the large loop or the four cysteine amino acid residues in both loops of said somatotropin.

    摘要翻译： 本发明涉及新颖的改性或衍生的重组动物生长激素。 所以本发明提供了用于稳定通过修饰或半胱氨酸残基利用位点定向诱变的缺失重组动物生长激素从一个与一个或多个不同的氨基酸残基，或通过衍生化替换到所述生长激素的半胱氨酸氨基酸残基的四种方法（ 1）两个半胱氨酸氨基酸残基在说生长激素的小环，在大环两个半胱氨酸氨基酸残基或所述生长激素两个环的4个半胱氨酸氨基酸残基。