发明公开
- 专利标题： Viper venom Polypeptides and variants
- 专利标题（中）： 多肽和deren变种aus dem礼物冯Schlangen。
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申请号： EP90301181.5申请日： 1990-02-05
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公开(公告)号： EP0382451A2公开(公告)日： 1990-08-16
- 发明人: Friedman, Paul A. , Jacobs, John W. , Gould, Robert J. , Polokoff, Mark A. , Gan, Zhong-Ru , Niewiarowski, Stefan , Holt, John C. , Rucinski, Boguslaw , Williams, Janice A.
- 申请人： MERCK & CO. INC. , TEMPLE UNIVERSITY
- 申请人地址： 126, East Lincoln Avenue P.O. Box 2000 Rahway New Jersey 07065-0900 US
- 专利权人： MERCK & CO. INC.,TEMPLE UNIVERSITY
- 当前专利权人： MERCK & CO. INC.,TEMPLE UNIVERSITY
- 当前专利权人地址： 126, East Lincoln Avenue P.O. Box 2000 Rahway New Jersey 07065-0900 US
- 代理机构： Cole, William Gwyn
- 优先权： US307642 19890207
- 主分类号： C07K7/10
- IPC分类号： C07K7/10 ; A61K37/02
摘要：
A platelet aggregation inhibiting polypeptide having the following amino acid sequence:
X-Cys-R-R-R-Arg-Gly-Asp-R-R-R-R-R-Cys-Y
wherein X is H or at least one amino acid; Y is OH or at least one amino acid; and each R, either the same or different, is any amino acid.
Polypeptides having this sequence are potent inhibitors of fibrinogen binding to receptors expressed on the glycoprotein IIb/IIIa complex in the membrane of platelets, and are therefore potent inhibitors of fibrinogen-induced human platelet aggregation. They are useful in inhibition of platelet aggregation formation.
X-Cys-R-R-R-Arg-Gly-Asp-R-R-R-R-R-Cys-Y
wherein X is H or at least one amino acid; Y is OH or at least one amino acid; and each R, either the same or different, is any amino acid.
Polypeptides having this sequence are potent inhibitors of fibrinogen binding to receptors expressed on the glycoprotein IIb/IIIa complex in the membrane of platelets, and are therefore potent inhibitors of fibrinogen-induced human platelet aggregation. They are useful in inhibition of platelet aggregation formation.
公开/授权文献
- EP0382451A3 Viper venom Polypeptides and variants 公开/授权日：1991-05-29
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