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公开(公告)号：EP0382451A3
公开(公告)日：1991-05-29
申请号：EP90301181.5
申请日：1990-02-05
发明人： Friedman, Paul A. , Jacobs, John W. , Gould, Robert J. , Polokoff, Mark A. , Gan, Zhong-Ru , Niewiarowski, Stefan , Holt, John C. , Rucinski, Boguslaw , Williams, Janice A.
摘要： A platelet aggregation inhibiting polypeptide having the following amino acid sequence:
X-Cys-R-R-R-Arg-Gly-Asp-R-R-R-R-R-Cys-Y
wherein X is H or at least one amino acid; Y is OH or at least one amino acid; and each R, either the same or different, is any amino acid. Polypeptides having this sequence are potent inhibitors of fibrinogen binding to receptors expressed on the glycoprotein IIb/IIIa complex in the membrane of platelets, and are therefore potent inhibitors of fibrinogen-induced human platelet aggregation. They are useful in inhibition of platelet aggregation formation.摘要翻译： 具有下列氨基酸序列的血小板聚集抑制多肽：X-Cys-R-R-R-Arg-Gly-Asp-R-R-R-R-R-Cys-Y其中X是H或至少一个氨基酸; Y是OH或至少一个氨基酸; 并且每个R，相同或不同，是任何氨基酸。 具有该序列的多肽是纤维蛋白原与血小板膜中糖蛋白IIb / IIIa复合物上表达的受体结合的有效抑制剂，因此是纤维蛋白原诱导的人血小板聚集的有效抑制剂。 它们可用于抑制血小板聚集形成。
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公开(公告)号：EP0382451A2
公开(公告)日：1990-08-16
申请号：EP90301181.5
申请日：1990-02-05
发明人： Friedman, Paul A. , Jacobs, John W. , Gould, Robert J. , Polokoff, Mark A. , Gan, Zhong-Ru , Niewiarowski, Stefan , Holt, John C. , Rucinski, Boguslaw , Williams, Janice A.
摘要： A platelet aggregation inhibiting polypeptide having the following amino acid sequence:
X-Cys-R-R-R-Arg-Gly-Asp-R-R-R-R-R-Cys-Y
wherein X is H or at least one amino acid; Y is OH or at least one amino acid; and each R, either the same or different, is any amino acid.
Polypeptides having this sequence are potent inhibitors of fibrinogen binding to receptors expressed on the glycoprotein IIb/IIIa complex in the membrane of platelets, and are therefore potent inhibitors of fibrinogen-induced human platelet aggregation. They are useful in inhibition of platelet aggregation formation.摘要翻译： 具有以下氨基酸序列的血小板聚集抑制多肽：X-Cys-R-R-R-Arg-Gly-Asp-R-R-R-R-R-Cys-Y，其中X为H或至少一个氨基酸; Y是OH或至少一个氨基酸; 并且每个R相同或不同，是任何氨基酸。 具有该序列的多肽是与血小板膜上的糖蛋白IIb / IIIa复合体上表达的受体结合的纤维蛋白原的有效抑制剂，因此是纤维蛋白原诱导的人血小板聚集的有效抑制剂。 它们可用于抑制血小板聚集形成。
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3.发明公开Trigramin- a platelet aggregation inhibiting polypeptide 失效Trigramin，ein Polypeptid，das die Aggregation derBlutplättchenhemmt。
公开(公告)号：EP0317053A2
公开(公告)日：1989-05-24
申请号：EP88307818.0
申请日：1988-08-24
发明人： Huang, Tur-Fu, c/o National Taiwan University , Niewiarowski, Stefan , Holt, John C. , Lukasiewicz, Hanna
摘要： Trigramin, a 72-amino acid polypeptide, has the following amino acid sequence: EAGEDCDCGSPANPCCDAATCKLIPGAQCGEGLCCDQCSFIEEGTVCRIARGDDLDDYCNGRSAGCPRNPFH. The molecule is a potent inhibitor of fibrinogen binding to receptors expressed on the glycoprotein IIb/IIIa complex in the membrane of platelets. Trigramin is thus a potent inhibitor of fibrinogen-induced human platelet aggregation. It is useful in inhibiting the formation of hemostatic platelet plugs.
摘要翻译： 特拉曲林是一个72个氨基酸的多肽，具有以下氨基酸序列：EAGEDCDCGSPANPCCDAATCKLIPGAQCGEGLCCDQCSFIEEGTVCRIARGDDLDDYCNGRSAGCPRNPFH。 该分子是与血小板膜上的糖蛋白IIb / IIIa复合体上表达的受体结合的纤维蛋白原的有效抑制剂。 因此，Trigramin是纤维蛋白原诱导的人血小板聚集的有效抑制剂。 它可用于抑制止血血小板塞的形成。
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公开(公告)号：EP0317053B1
公开(公告)日：1993-12-08
申请号：EP88307818.0
申请日：1988-08-24
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公开(公告)号：EP0317053A3
公开(公告)日：1990-07-25
申请号：EP88307818.0
申请日：1988-08-24
发明人： Huang, Tur-Fu, c/o National Taiwan University , Niewiarowski, Stefan , Holt, John C. , Lukasiewicz, Hanna
摘要： Trigramin, a 72-amino acid polypeptide, has the following amino acid sequence: EAGEDCDCGSPANPCCDAATCKLIPGAQCGEGLCCDQCSFIEEGTVCRIARGDDLDDYCNGRSAGCPRNPFH. The molecule is a potent inhibitor of fibrinogen binding to receptors expressed on the glycoprotein IIb/IIIa complex in the membrane of platelets. Trigramin is thus a potent inhibitor of fibrinogen-induced human platelet aggregation. It is useful in inhibiting the formation of hemostatic platelet plugs.
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