发明公开
- 专利标题: A stabilized antitumor composition
- 专利标题(中): 稳定性抗肿瘤药。
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申请号: EP90104007.1申请日: 1990-03-01
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公开(公告)号: EP0385468A1公开(公告)日: 1990-09-05
- 发明人: Hosoi, Kaoru, c/o Pharmaceutical Research Center , Ishizawa, Takayuki, Pharmaceutical Research Center , Okada, Makoto, Pharmaceutical Research Center , Yoneta, Toshio, Pharmaceutical Research Center , Murata, Shinjiro, Pharmaceutical Research Center , Fukatsu, Shunzo, Pharmaceutical Research Center , Tsuchiya, Tsutomu
- 申请人: MEIJI SEIKA KAISHA LTD. , ZAIDAN HOJIN BISEIBUTSU KAGAKU KENKYU KAI
- 申请人地址: 4-16 Kyobashi 2-chome Chuo-ku Tokyo 104 JP
- 专利权人: MEIJI SEIKA KAISHA LTD.,ZAIDAN HOJIN BISEIBUTSU KAGAKU KENKYU KAI
- 当前专利权人: MEIJI SEIKA KAISHA LTD.,ZAIDAN HOJIN BISEIBUTSU KAGAKU KENKYU KAI
- 当前专利权人地址: 4-16 Kyobashi 2-chome Chuo-ku Tokyo 104 JP
- 代理机构: VOSSIUS & PARTNER
- 优先权: JP48488/89 19890302
- 主分类号: A61K31/71
- IPC分类号: A61K31/71 ; A61K47/26 ; A61K9/14
摘要:
According to this invention there is provided a new stabilized antitumor composition comprising a mixture of an antitumor anthracycline compound of formula (I)
or a non-toxic salt thereof with lactose, with the lactose being incorporated as a stabilizing agent in the mixture in an amount effective to stabilize the anthracycline compound of formula (I) or its salt from its degradation and thus with the weight ratio between the anthracycline compound or its salt and lactose being in a range of 1 : 0.5 to 1 : 8. There is also provided a method for stabilizing the anthracycline compound of formula (I) or its salt by mixing with lactose in the required proportions.
or a non-toxic salt thereof with lactose, with the lactose being incorporated as a stabilizing agent in the mixture in an amount effective to stabilize the anthracycline compound of formula (I) or its salt from its degradation and thus with the weight ratio between the anthracycline compound or its salt and lactose being in a range of 1 : 0.5 to 1 : 8. There is also provided a method for stabilizing the anthracycline compound of formula (I) or its salt by mixing with lactose in the required proportions.
公开/授权文献
- EP0385468B1 A stabilized antitumor composition 公开/授权日:1992-08-26
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